Mazza Marianna, Martini Annalisa, Scoppetta Marta, Mazza Salvatore
Institute of Psychiatry and Psychology, Catholic University of Sacred Heart, Rome, Via Ugo De Carolis, 48 00136 Rome, Italy.
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):539-43. doi: 10.1016/j.pnpbp.2007.10.015. Epub 2007 Oct 30.
Interictal depression is common in patients with epilepsy and it significantly impacts quality of life. Some studies indicate that levetiracetam (LEV) may have mood stabilizing properties.
Twenty-five adults with uncontrolled partial seizures and concomitant depressive symptoms were treated with LEV. Patients were evaluated for depression and anxiety with several psychometric measures, including: Montgomery and Asberg Depression Rating Scale (MADRS), Hamilton Depression Rating Scale (HDRS), Zung Self-rating Scale for Depression (Z-SDS), Hamilton Anxiety Rating Scale (HARS), Zung Self-rating Scale for Anxiety (Z-SAS).
Evaluations after 5 weeks and after 3 months of LEV treatment demonstrated significant improvement in depression and anxiety.
This uncontrolled study suggests that treatment with LEV may also improve depression and anxiety in patients with partial seizures. However, the sample of patients is limited and the possibility of a placebo effect cannot be excluded. These findings must be considered preliminary and should be replicated under placebo-controlled conditions.
发作间期抑郁在癫痫患者中很常见，且会显著影响生活质量。一些研究表明，左乙拉西坦（LEV）可能具有情绪稳定特性。
25名伴有难治性部分性癫痫发作及抑郁症状的成年患者接受了左乙拉西坦治疗。采用多种心理测量方法对患者的抑郁和焦虑情况进行评估，包括：蒙哥马利-艾斯伯格抑郁评定量表（MADRS）、汉密尔顿抑郁评定量表（HDRS）、zung抑郁自评量表（Z-SDS）、汉密尔顿焦虑评定量表（HARS）、zung焦虑自评量表（Z-SAS）。
左乙拉西坦治疗5周及3个月后的评估显示，抑郁和焦虑情况有显著改善。
这项非对照研究表明，左乙拉西坦治疗可能也会改善部分性癫痫患者的抑郁和焦虑情况。然而，患者样本有限，且不能排除安慰剂效应的可能性。这些发现必须被视为初步结果，应在安慰剂对照条件下进行重复验证。
