Mehvari-Habibabadi Jafar, Zare Mohammad, Aghaye-Ghazvini Mohammad Reza, Rahnama Maryam
Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
National Institute of Health Research, Tehran University of Medical Sciences, Tehran, Iran.
Curr J Neurol. 2022 Oct 7;21(4):224-229. doi: 10.18502/cjn.v21i4.11719.
Levetiracetam (LEV) is approved for treating epilepsy. The current evidence shows that LEV can cause behavioral problems such as depression. It is well-known that depression is associated with oxidative stress. Therefore, we conducted this study to assess the influence of LEV on depression severity and anti-oxidant status. In this prospective longitudinal study, 50 patients with diagnosis of epilepsy on LEV were included. We used Beck Depression Inventory-II (BDI-II) to assess depression severity. The serum levels of zinc and glutathione were measured as anti-oxidant markers. These variables were evaluated at the baseline and 3 months after the commencement of LEV. A total of 30 patients finished the follow-up. Among them, 21 patients were women. The mean age at baseline was 28.76 ± 11.37 (range: 16-68 years). The severity of depression at the last follow-up was significantly higher than the baseline. We observed a decrease in the serum levels of zinc and glutathione, though they were not statistically significant. Our results suggest that LEV can increase the risk of depression in patients with epilepsy. This study also suggests that zinc depletion can be induced through act of LEV. Further studies are needed to validate these findings.
左乙拉西坦（LEV）被批准用于治疗癫痫。目前的证据表明，LEV可导致诸如抑郁等行为问题。众所周知，抑郁与氧化应激有关。因此，我们开展了这项研究，以评估LEV对抑郁严重程度和抗氧化状态的影响。在这项前瞻性纵向研究中，纳入了50例诊断为癫痫且正在服用LEV的患者。我们使用贝克抑郁量表第二版（BDI-II）来评估抑郁严重程度。测量血清锌和谷胱甘肽水平作为抗氧化标志物。这些变量在基线时以及LEV开始服用3个月后进行评估。共有30例患者完成了随访。其中，21例为女性。基线时的平均年龄为28.76±11.37（范围：16 - 68岁）。最后一次随访时的抑郁严重程度显著高于基线。我们观察到血清锌和谷胱甘肽水平有所下降，尽管它们在统计学上无显著意义。我们的结果表明，LEV可增加癫痫患者患抑郁的风险。这项研究还表明，LEV的作用可导致锌缺乏。需要进一步研究来验证这些发现。
