Taylor C R, Hodge E M, White D A
Pfizer Central Research, Groton.
Postgrad Med J. 1991;67 Suppl 5:S59.
A clear circadian rhythm exists for angina, with the frequency of attacks increasing during the mid-morning and mid-afternoon hours. This pattern is comparable to circadian rhythms previously reported for the incidence of myocardial infarction and sudden cardiac death. The frequency of angina attacks precipitated by physical exertion showed a more pronounced circadian pattern compared to non-exertional angina. Beta-adrenergic blocking agents did not abolish the circadian rhythm of total angina and exertional angina attacks.
心绞痛存在明显的昼夜节律，发作频率在上午和下午中段时间增加。这种模式与先前报道的心肌梗死和心源性猝死发生率的昼夜节律相似。与非劳力性心绞痛相比，体力活动诱发的心绞痛发作频率呈现出更明显的昼夜模式。β-肾上腺素能阻滞剂并未消除总心绞痛和劳力性心绞痛发作的昼夜节律。
