Taylor C R, Hodge E M, White D A
Pfizer International Inc., 235 East 42nd Street, New York, NY 10017, USA.
J Cardiovasc Pharmacol. 1991;17 Suppl 1:S43-5. doi: 10.1097/00005344-199117001-00014.
Analysis of diary card data from 33,999 angina attacks recorded in 1,022 patients with chronic stable angina showed a clear circadian pattern to the frequency of angina that resembles patterns previously described for myocardial infarction and sudden cardiac death, with a peak in the morning. The majority of angina attacks were preceded by physical exertion and the circadian pattern was more pronounced for exertional angina than nonexertional angina. In this study, treatment with beta-blockers did not prevent the morning peak of angina attacks.
对1022例慢性稳定性心绞痛患者记录的33999次心绞痛发作的日记卡数据进行分析，结果显示，心绞痛发作频率呈现明显的昼夜节律模式，类似于先前描述的心肌梗死和心源性猝死的模式，且在早晨达到峰值。大多数心绞痛发作之前有体力活动，劳力性心绞痛的昼夜节律模式比非劳力性心绞痛更为明显。在本研究中，β受体阻滞剂治疗未能预防心绞痛发作的早晨峰值。
