Harder B, Hennerici M G, Jonas J B
Universitätsaugenklinik, Medizinische Fakultät Mannheim der Ruprecht-Karls-Universität Heidelberg.
Klin Monbl Augenheilkd. 2007 Nov;224(11):852-5. doi: 10.1055/s-2007-963634.
The diagnosis of idiopathic intracranial hypertension results from a synopsis of standardised examinations including MRI. Since the cerebrospinal fluid pressure influences the pressure of the central retinal vein, it was the purpose of the present study to evaluate whether the ophthalmodynamometric estimation of the central retinal vein collapse pressure is helpful for the diagnosis of idiopathic intracranial hypertension.
The study included 5 patients with idiopathic intracranial hypertension with a mean age of 38.3+/-10.8 years and 88 subjects of a control group with a mean age of 66.8+/-13.1 years. Using a modified corneal contact lens-associated ophthalmodynamometry, the collapse pressure of the central retinal vein was estimated.
The central retinal vein collapse pressure was significantly higher in the study group (33.0+/-27.3 relative units) than in the control group (2.0+/-6.7 relative units) (p<0.006; 95 % confidence interval: -11.5, 50.5). The central retinal artery collapse pressure did not vary significantly between the two groups (52.7+/-15.3 relative units versus 65.6+/-20.4 relative units; p=0.19; 95 % confidence interval: -36.6, 10.5).
The corneal contact lens-associated ophthalmodynamometry can be helpful for the monitoring of patients with intracranial idiopathic hypertension.
特发性颅内高压的诊断基于包括磁共振成像(MRI)在内的标准化检查结果汇总。由于脑脊液压力会影响视网膜中央静脉压力,本研究旨在评估通过眼压计测量视网膜中央静脉塌陷压力是否有助于特发性颅内高压的诊断。
本研究纳入了5例特发性颅内高压患者,平均年龄为38.3±10.8岁,以及88名对照组受试者,平均年龄为66.8±13.1岁。使用改良的角膜接触镜相关眼压计测量视网膜中央静脉的塌陷压力。
研究组的视网膜中央静脉塌陷压力(33.0±27.3相对单位)显著高于对照组(2.0±6.7相对单位)(p<0.006;95%置信区间:-11.5,50.5)。两组之间视网膜中央动脉塌陷压力无显著差异(52.7±15.3相对单位对65.6±20.4相对单位;p=0.19;95%置信区间:-36.6,10.5)。
角膜接触镜相关眼压计有助于监测颅内特发性高血压患者。