Jonas Jost B
Department of Ophthalmology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
Graefes Arch Clin Exp Ophthalmol. 2003 May;241(5):367-70. doi: 10.1007/s00417-003-0643-7. Epub 2003 Apr 16.
Using a new Goldmann contact lens associated ophthalmodynamometric device, it was the purpose of the present study to determine the central retinal vein collapse pressure in eyes with retinal vein occlusions or retinal venous stasis.
The prospective clinical non-interventional comparative study included 19 patients with central retinal vein occlusion ( n=8), branch retinal vein occlusion (n=4), or retinal venous stasis (n=7) and 42 subjects of a control group. With topical anesthesia, a Goldmann contact lens fitted with a pressure sensor was put onto the cornea. Pressure was exerted on the globe by pressing the contact lens, and the pressure value at the time when the central retinal vein started pulsating was noted.
Central retinal vein collapse pressure measured 103.6+/-25.4 arbitrary units (AU) in eyes with central retinal vein occlusion what was significantly higher than in the eyes with retinal venous stasis (58.1+/-37.5 AU; p=0.02) and the eyes with branch retinal vein occlusion (43.8+/-25.5 AU; p=0.004). In the latter two groups, the measurements of the central retinal vein collapse pressure were significantly (p<0.001) higher than the measurements in the eyes of the control group (4.2+/-7.8 AU).
As measured by a new ophthalmodynamometer with direct biomicroscopic visualization of the central retinal vessels during examination, central retinal vein collapse pressure is significantly higher in eyes with central retinal vein occlusion, followed by eyes with branch retinal vein occlusion, eyes with retinal venous stasis and, finally, normal eyes. These findings may have diagnostic and therapeutic implications.
本研究旨在使用一种新型的与戈德曼接触镜相关的眼血流动力学测量装置，测定视网膜静脉阻塞或视网膜静脉淤滞患者的视网膜中央静脉塌陷压力。
这项前瞻性临床非干预性对比研究纳入了19例视网膜中央静脉阻塞患者（n = 8）、视网膜分支静脉阻塞患者（n = 4）或视网膜静脉淤滞患者（n = 7）以及42名对照组受试者。在表面麻醉下，将配有压力传感器的戈德曼接触镜放置在角膜上。通过按压接触镜对眼球施加压力，并记录视网膜中央静脉开始搏动时的压力值。
视网膜中央静脉阻塞患者的视网膜中央静脉塌陷压力测量值为103.6±25.4任意单位（AU），显著高于视网膜静脉淤滞患者（58.1±37.5 AU；p = 0.02）和视网膜分支静脉阻塞患者（43.8±25.5 AU；p = 0.004）。在后两组中，视网膜中央静脉塌陷压力测量值显著高于对照组受试者的测量值（4.2±7.8 AU；p < 0.001）。
通过一种新型眼血流动力学测量仪在检查过程中直接在生物显微镜下观察视网膜中央血管来测量，视网膜中央静脉塌陷压力在视网膜中央静脉阻塞患者中显著更高，其次是视网膜分支静脉阻塞患者、视网膜静脉淤滞患者，最后是正常眼。这些发现可能具有诊断和治疗意义。
