Bourin Michel, Petit-Demoulière Benoit, Dhonnchadha Brid Nic, Hascöet Martine
EA 3256 Neurobiologie de l'anxiété et de la dépression Faculté de Médecine 1, rue Gaston Veil, BP 53508, 44035 Nantes Cedex 01, France.
Fundam Clin Pharmacol. 2007 Dec;21(6):567-74. doi: 10.1111/j.1472-8206.2007.00526.x.
Among the multiple possibilities to study human pathologies, animal models remain one of the most used pathways. They allow to access to unavailable answers in human patients and to learn about mechanisms of action of drugs. Primarily developed with rats, animal models in anxiety have been adapted with a mixed success for mice, an easy-to-use mammal with better genetic possibilities than rats. In this review, we have focused on the most used animal models in anxiety in mice. Both conditioned and unconditioned models are described, to represent all types of animal models of anxiety. Behavioural studies require strong care for variable parameters, linked to environment, handling or paradigm; we have discussed about this topic. Finally, we focused on the consequences of re-exposure to the apparatus. Test-retest procedures can bring in new answers, but should be deeply studied, to revalidate the whole paradigm as an animal model of anxiety.
在研究人类病理学的多种可能性中，动物模型仍然是最常用的途径之一。它们使我们能够获得人类患者无法得到的答案，并了解药物的作用机制。动物焦虑模型最初主要是用大鼠建立的，对于小鼠而言，虽然经过了一定程度的调整，但效果不一。小鼠是一种易于使用的哺乳动物，其遗传可能性比大鼠更好。在这篇综述中，我们重点关注了小鼠中最常用的焦虑动物模型。文中描述了条件性和非条件性模型，以涵盖所有类型的焦虑动物模型。行为学研究需要特别关注与环境、处理方式或实验范式相关的可变参数；我们已就此主题进行了讨论。最后，我们关注了再次暴露于实验装置的后果。重复测试程序可能会带来新的答案，但需要深入研究，以便重新验证整个范式作为焦虑动物模型的有效性。
