Nair Anuska P, Mallya Shailaja
Department of Pharmacology, Goa College of Pharmacy, Panaji, Goa, India.
Indian J Pharmacol. 2025 May 1;57(3):145-149. doi: 10.4103/ijp.ijp_288_23. Epub 2025 Jul 9.
The current study sought to assess the anxiolytic effects of a methanolic extract of Biophytum sensitivum (L) DC leaves.
In vivo screening methods such as the elevated plus maze model, light and dark chamber model, and mirror chamber apparatus were used to study the anxiolytic behavior, using Wistar albino rats. Methanolic extract of B. sensitivum (MEBS) leaves and was administered orally at a dose of 200 mg and 400 mg/kg.
The methanolic extract of the leaves of B. sensitivum exhibited a dose-dependent anxiolytic activity.
The MEBS showed anxiolytic activity and showed results which were comparable to the standard drugs used. The total flavonoid content test confirmed the presence of flavonoids, which may have a role in the anxiolytic activity.
本研究旨在评估含羞草叶甲醇提取物的抗焦虑作用。
采用高架十字迷宫模型、明暗箱模型和镜像箱装置等体内筛选方法，以Wistar白化大鼠研究抗焦虑行为。含羞草叶甲醇提取物（MEBS）以200 mg和400 mg/kg的剂量口服给药。
含羞草叶甲醇提取物表现出剂量依赖性抗焦虑活性。
MEBS显示出抗焦虑活性，其结果与所用标准药物相当。总黄酮含量测试证实了黄酮类化合物的存在，其可能在抗焦虑活性中起作用。
