Zbranca E, Preda C
Endocrinology Clinic, Institute of Medicine and Pharmacy, Iasi, Romania.
Endocrinologie. 1991;29(1-2):91-7.
Prostate cancer is one of the most current diseases in elderly men and contributes greatly to the increase in mortality, morbidity and cost of health care. An adequate therapeutical approach requires a whole set of methods for establishing a correct histologic diagnosis and evaluating the local and general spread of the disease. As most of the neoplastic cells in the prostate are at least partly androgen-dependent, the goal of the hormonal therapy is to deprive them of androgenic hormones and their derivatives. On this purpose, the most important means of the hormonal therapy, starting with the traditional ones (orchidectomy, hypophysectomy, adrenalectomy, androgens administration) and ending with the latest achievements (anti-androgens, antiestrogens, LH--RH analogous) are scrutinized, making specific recommendations as to their indications, way of administration and effectiveness.
前列腺癌是老年男性中最常见的疾病之一，对死亡率、发病率和医疗保健成本的增加有很大影响。一种适当的治疗方法需要一整套用于建立正确组织学诊断和评估疾病局部及全身扩散情况的方法。由于前列腺中的大多数肿瘤细胞至少部分依赖雄激素，激素治疗的目标是剥夺它们的雄激素及其衍生物。为此，对激素治疗的最重要手段进行了详细审查，从传统方法（睾丸切除术、垂体切除术、肾上腺切除术、雄激素给药）到最新成果（抗雄激素、抗雌激素、促性腺激素释放激素类似物），并就其适应症、给药方式和有效性提出了具体建议。
