Spiegelhalder Kai, Hornyak Magdolna
Sleep Disorders Center, Department of Psychiatry and Psychotherapy, University Hospital Freiburg, Hauptstrasse 5, D-79104 Freiburg, Germany.
Clin Geriatr Med. 2008 Feb;24(1):167-80, ix. doi: 10.1016/j.cger.2007.08.004.
Restless legs syndrome (RLS) is a common neurological disorder characterized by an urge to move the legs. The symptoms show a strong circadian rhythmicity, with onset or increase in the evening or at night; thus, sleep disturbances are the most frequent reason for patients seeking medical aid. The prevalence of the disorder increases strongly with age, with an estimated 9% to 20% of sufferers being among the elderly. Dopaminergic drugs are the first-line treatment option in RLS; opioids and anticonvulsants can also be used either as add-on or stand alone therapy options. Secondary forms of RLS and possible interaction with other medications require particular consideration in the elderly.
不安腿综合征（RLS）是一种常见的神经系统疾病，其特征是腿部有活动的冲动。症状表现出强烈的昼夜节律性，在傍晚或夜间发作或加重；因此，睡眠障碍是患者寻求医疗帮助的最常见原因。该疾病的患病率随年龄增长而大幅上升，估计老年患者中有9%至20%患有此病。多巴胺能药物是RLS的一线治疗选择；阿片类药物和抗惊厥药物也可作为附加治疗或单独治疗方案使用。RLS的继发性形式以及与其他药物可能的相互作用在老年人中需要特别考虑。
