为期12周的瑜伽与为期12周的教育影片干预对不安腿综合征症状及相关结果的影响：一项探索性随机对照试验。
Effects of a 12-week yoga versus a 12-week educational film intervention on symptoms of restless legs syndrome and related outcomes: an exploratory randomized controlled trial.
作者信息
Innes Kim E, Selfe Terry Kit, Montgomery Caitlin, Hollingshead Nicole, Huysmans Zenzi, Srinivasan Roshini, Wen Sijin, Hausmann Madeleine J, Sherman Karen, Klatt Maryanna
机构信息
Department of Epidemiology, West Virginia University School of Public Health, Morgantown, West Virginia.
Health Science Center Libraries, University of Florida, Gainesville, Florida.
出版信息
J Clin Sleep Med. 2020 Jan 15;16(1):107-119. doi: 10.5664/jcsm.8134.
STUDY OBJECTIVES
To assess the effects of a yoga versus educational film (EF) program on restless legs syndrome (RLS) symptoms and related outcomes in adults with RLS.
METHODS
Forty-one community-dwelling, ambulatory nonpregnant adults with moderate to severe RLS were randomized to a 12-week yoga (n = 19) or EF program (n = 22). In addition to attending classes, all participants completed practice/treatment logs. Yoga group participants were asked to practice at home 30 minutes per day on nonclass days; EF participants were instructed to record any RLS treatments used on their daily logs. Core outcomes assessed pretreatment and posttreatment were RLS symptoms and symptom severity (International RLS Study Group Scale (IRLS) and RLS ordinal scale), sleep quality, mood, perceived stress, and quality of life (QOL).
RESULTS
Thirty adults (13 yoga, 17 EF), aged 24 to 73 (mean = 50.4 ± 2.4 years), completed the 12-week study (78% female, 80.5% white). Post-intervention, both groups showed significant improvement in RLS symptoms and severity, perceived stress, mood, and QOL-mental health (P ≤ .04). Relative to the EF group, yoga participants demonstrated significantly greater reductions in RLS symptoms and symptom severity (P ≤ .01), and greater improvements in perceived stress and mood (P ≤ .04), as well as sleep quality (P = .09); RLS symptoms decreased to minimal/mild in 77% of yoga group participants, with none scoring in the severe range by week 12, versus 24% and 12%, respectively, in EF participants. In the yoga group, IRLS and RLS severity scores declined with increasing minutes of homework practice (r = .7, P = .009 and r = .6, P = .03, respectively), suggesting a possible dose-response relationship.
CONCLUSIONS
Findings of this exploratory RCT suggest that yoga may be effective in reducing RLS symptoms and symptom severity, decreasing perceived stress, and improving mood and sleep in adults with RLS.
CLINICAL TRIAL REGISTRATION
Registry: Clinicaltrials.gov; Title: Yoga vs. Education for Restless Legs: a Feasibility Study; Identifier: NCT03570515; URL: https://clinicaltrials.gov/ct2/show/NCT03570515.
研究目的
评估瑜伽与教育影片（EF）项目对成年不安腿综合征（RLS）患者的RLS症状及相关结局的影响。
方法
41名社区居住、非卧床、非妊娠的中重度RLS成年患者被随机分为12周的瑜伽组（n = 19）或EF组（n = 22）。除参加课程外，所有参与者均完成练习/治疗日志。瑜伽组参与者被要求在非上课日每天在家练习30分钟；EF组参与者被指示在其每日日志中记录所使用的任何RLS治疗方法。评估的治疗前和治疗后的核心结局为RLS症状和症状严重程度（国际RLS研究组量表（IRLS）和RLS序数量表）、睡眠质量、情绪、感知压力和生活质量（QOL）。
结果
30名年龄在24至73岁（平均 = 50.4 ± 2.4岁）的成年人（13名瑜伽组，17名EF组）完成了为期12周的研究（78%为女性，80.5%为白人）。干预后，两组在RLS症状和严重程度、感知压力、情绪和QOL心理健康方面均有显著改善（P≤0.04）。相对于EF组，瑜伽组参与者在RLS症状和症状严重程度方面的降低更为显著（P≤0.01），在感知压力和情绪方面的改善更大（P≤0.04），睡眠质量方面也有改善（P = 0.09）；瑜伽组77%的参与者RLS症状降至最小/轻度，到第12周时无人处于严重范围，而EF组参与者分别为24%和12%。在瑜伽组中，IRLS和RLS严重程度评分随着家庭作业练习分钟数的增加而下降（r = 0.7，P = 0.009和r = 0.6，P = 0.03），表明可能存在剂量反应关系。
结论
这项探索性随机对照试验的结果表明，瑜伽可能有效地减轻成年RLS患者的RLS症状和症状严重程度，降低感知压力，改善情绪和睡眠。
临床试验注册
注册机构：Clinicaltrials.gov；标题：瑜伽与不安腿教育：一项可行性研究；标识符：NCT03570515；网址：https://clinicaltrials.gov/ct2/show/NCT03570515 。
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