Ferri Clodoveo, Antonelli Alessandro, Mascia Maria Teresa, Sebastiani Marco, Fallahi Poupak, Ferrari Daniela, Giunti Marco, Pileri Stefano A, Zignego Anna Linda
Chair and Rheumatology Unit, Department of Internal Medicine, University of Modena & Reggio E., Medical School, Modena, Italy.
Autoimmun Rev. 2007 Dec;7(2):114-20. doi: 10.1016/j.autrev.2007.02.019. Epub 2007 Mar 28.
Mixed cryoglobulinemia (MC) is a systemic small-vessel vasculitis; B-cell expansion is the biological substrate of the disease. It can be regarded as benign lymphoproliferative condition that may evolve to frank lymphoma. HCV infection is the main causative factor of MC, as well as of other overlapping disorders, through multifactorial and multistep pathogenetic process. HCV-related B-cell proliferation represents an important model of virus-driven autoimmune/neoplastic disorder. The term HCV syndrome is referred to a wide spectrum of both hepatic and extrahepatic disorders. The present review analyzes the complex virological, clinico-pathological, and therapeutic implications of B-cell proliferation, with or without HCV infection, in MC patients.
混合性冷球蛋白血症（MC）是一种全身性小血管炎；B细胞增殖是该疾病的生物学基础。它可被视为一种可能演变为明显淋巴瘤的良性淋巴增殖性疾病。丙型肝炎病毒（HCV）感染是MC以及其他重叠性疾病的主要致病因素，其致病过程涉及多因素和多步骤。HCV相关的B细胞增殖代表了病毒驱动的自身免疫/肿瘤性疾病的一个重要模型。HCV综合征这一术语指的是广泛的肝脏和肝外疾病。本综述分析了MC患者中无论有无HCV感染时B细胞增殖的复杂病毒学、临床病理及治疗意义。
