Dzizinskiĭ A A, Tumak V N, Zhatkin S I
Ter Arkh. 1991;63(12):35-7.
The effect of conventional and prolonged epidural analgesia (PEA) with morphine on the clinical course and the size of the focus of necrosis was studied and compared in 60 patients with acute myocardial infarction. In the basic group (n = 30), analgesia was carried out for 7 days with the aid of PEA. In the control group (n = 30), analgesia was performed by intravenous injection of morphine. In both the groups, the clinical course ant the size of the focus of myocardial necrosis were estimated (precordial cartography and detection of creatine phosphokinase made in series). PEA was established to bring about complete analgesia rapidly and safely, which in turn favours noticeable limitation of the focus of necrosis and amelioration of the clinical course of acute myocardial infarction. The effect produced by PEA was considerably higher in all the parameters as compared to that attained with conventional analgesia.
在60例急性心肌梗死患者中，研究并比较了常规硬膜外镇痛和延长硬膜外镇痛（PEA）联合吗啡对临床病程及坏死灶大小的影响。基础组（n = 30）借助PEA进行7天镇痛。对照组（n = 30）通过静脉注射吗啡进行镇痛。两组均评估了临床病程及心肌坏死灶大小（进行系列心前区心电图描记和肌酸磷酸激酶检测）。结果表明，PEA能迅速、安全地实现完全镇痛，进而有利于显著限制坏死灶并改善急性心肌梗死的临床病程。与常规镇痛相比，PEA在所有参数上产生的效果都要高得多。
