Pratelli A
Department of Animal Health and Well-being, Strada Provinciale per Casamassima Km 3, 70010 Valenzano, Bari, Italy.
Zoonoses Public Health. 2007;54(9-10):383-6. doi: 10.1111/j.1863-2378.2007.01079.x.
Canine coronavirus (CCoV) is responsible for enteric disease in pups. Infected dogs generally have a rapid recovery, so the virus is highly contagious and the spread of infection is difficult to control. Chemical disinfectants have been widely used in human disease-control programmes to prevent viral infectious diseases from spreading, but to date, there are no studies in the literature on the sensitivity of CCoV to chemical biocides. The present study investigated the sensitivity of CCoV to disinfectants currently used for prophylaxis in kennel and dog breeding locations. The effects of three agents: alkyl-dimethyl-benzyl-ammonium chloride, benzalkonium chloride and didecyl-dimethyl-ammonium chloride, on the infectivity titre of CCoV in A72 cell lines, were studied at different concentrations. Although they may regard a small number of agents, the findings showed that the sensitivity of CCoV to disinfectants varies and the differences are dose correlated. In general, virus inactivation implies a permanent loss of infectivity which can be evaluated in suspensions and hand disinfection tests.
犬冠状病毒（CCoV）可引发幼犬的肠道疾病。受感染的犬类通常恢复迅速，因此该病毒具有高度传染性，感染传播难以控制。化学消毒剂已广泛应用于人类疾病防控项目，以防止病毒传染病传播，但迄今为止，文献中尚无关于CCoV对化学杀菌剂敏感性的研究。本研究调查了CCoV对目前用于犬舍和犬类繁殖场所预防的消毒剂的敏感性。研究了三种试剂：烷基二甲基苄基氯化铵、苯扎氯铵和双癸基二甲基氯化铵在不同浓度下对A72细胞系中CCoV感染滴度的影响。尽管研究的试剂数量较少，但结果表明CCoV对消毒剂的敏感性各不相同，且差异与剂量相关。一般来说，病毒失活意味着传染性的永久丧失，这可以在悬浮液和手部消毒试验中进行评估。
