5-羟色胺（5-HT）和5-羟色胺硫酸酯（5-HT-SO4），而非单馈神经元中的色氨酸或5-羟吲哚乙酸（5-HIAA）水平，会跟踪动物的饥饿状态。
5-HT and 5-HT-SO4, but not tryptophan or 5-HIAA levels in single feeding neurons track animal hunger state.
作者信息
Hatcher N G, Zhang X, Stuart J N, Moroz L L, Sweedler J V, Gillette R
机构信息
Department of Molecular & Integrative Physiology, Department of Chemistry and Beckman Institute, University of Illinois, Urbana, Illinois, USA.
出版信息
J Neurochem. 2008 Mar;104(5):1358-63. doi: 10.1111/j.1471-4159.2007.05084.x. Epub 2007 Nov 23.
Abstract
Serotonin (5-HT) is an intrinsic modulator of neural network excitation states in gastropod molluscs. 5-HT and related indole metabolites were measured in single, well-characterized serotonergic neurons of the feeding motor network of the predatory sea-slug Pleurobranchaea californica. Indole amounts were compared between paired hungry and satiated animals. Levels of 5-HT and its metabolite 5-HT-SO4 in the metacerebral giant neurons were observed in amounts approximately four-fold and two-fold, respectively, below unfed partners 24 h after a satiating meal. Intracellular levels of 5-hydroxyindole acetic acid and of free tryptophan did not differ significantly with hunger state. These data demonstrate that neurotransmitter levels and their metabolites can vary in goal-directed neural networks in a manner that follows internal state.
摘要
血清素（5-羟色胺，5-HT）是腹足纲软体动物神经网络兴奋状态的一种内在调节因子。在捕食性海蛞蝓加州侧鳃（Pleurobranchaea californica）摄食运动网络中，对单个、特征明确的5-羟色胺能神经元中的5-羟色胺及相关吲哚代谢产物进行了测量。比较了成对的饥饿动物和饱腹动物的吲哚含量。在一顿饱腹餐后24小时，发现中脑巨神经元中的5-羟色胺及其代谢产物5-羟色胺硫酸酯（5-HT-SO4）的水平分别比未进食的配对动物低约四倍和两倍。5-羟吲哚乙酸和游离色氨酸的细胞内水平在饥饿状态下没有显著差异。这些数据表明，神经递质水平及其代谢产物在目标导向神经网络中会随着内部状态而变化。
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