颞骨外侧切除术治疗耳部及颞骨恶性肿瘤后的管理结果。

Management outcomes following lateral temporal bone resection for ear and temporal bone malignancies.

作者信息

Moore Michael G, Deschler Daniel G, McKenna Michael J, Varvares Mark A, Lin Derrick T

机构信息

Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA.

出版信息

Otolaryngol Head Neck Surg. 2007 Dec;137(6):893-8. doi: 10.1016/j.otohns.2007.09.010.

DOI:10.1016/j.otohns.2007.09.010

PMID:18036417

Abstract

OBJECTIVE

To evaluate clinical outcomes following lateral temporal bone resection (LTBR) for management of malignancies involving the ear or temporal bone.

SUBJECTS AND METHODS

A retrospective medical record review was performed on patients receiving LTBR for management of malignancies involving the ear or temporal bone between 1990 and 2007.

RESULTS

In this group of 35 patients, the mean age was 62.7 years, with tumor histopathologies including squamous cell carcinoma (SCC, 20), basal cell carcinoma (BCC, 7), adenoid cystic carcinoma (ACC, 7), and adenocarcinoma (1). The 5-year overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) were 77%, 79%, and 52%, respectively. Complete resection resulted in improved OS, DSS, and DFS (P < 0.004 for each) and reduced local recurrence (P < 0.001).

CONCLUSIONS

In patients with carcinomas of the ear and temporal bone, upfront excision including LTBR is an effective management when combined with postoperative radiation therapy. Complete removal of all disease may improve survival and decrease recurrence.

摘要

目的

评估外侧颞骨切除术（LTBR）治疗耳部或颞骨恶性肿瘤的临床疗效。

研究对象与方法

对1990年至2007年间接受LTBR治疗耳部或颞骨恶性肿瘤的患者进行回顾性病历审查。

结果

在这组35例患者中，平均年龄为62.7岁，肿瘤组织病理学类型包括鳞状细胞癌（SCC，20例）、基底细胞癌（BCC，7例）、腺样囊性癌（ACC，7例）和腺癌（1例）。5年总生存率（OS）、疾病特异性生存率（DSS）和无病生存率（DFS）分别为77%、79%和52%。完整切除可提高OS、DSS和DFS（每项P<0.004）并降低局部复发率（P<0.001）。