Issing P R, Kempf H G, Schönermark M, Lenarz T
Klinik für Hals-Nasen-Ohren-Heilkunde, Medizinische Hochschule, Hannover.
Laryngorhinootologie. 1995 Nov;74(11):666-72. doi: 10.1055/s-2007-997822.
Carcinoma of the external ear canal and the middle ear is a rather rare event and is especially seen in patients with chronic inflammatory ear disease.
Between 1993 and 1994, we treated seven patients with such a tumor, of which six proved to be a squamous cell carcinoma and one presumably adenocarcinoma. In three patients, the malignoma developed in a radical cavity of the ear and caused a facial palsy. Only two patients were without any discharge of the ear. Beside facial palsy, hemorrhagic otorrhea and otalgia were the leading symptoms. One patient presented with a bilateral painless swelling of the neck due to lymph node metastasis. Diagnosis was made by means of biopsy in only three patients and on the basis of a resected specimen after mastoidectomy in four patients. Angiography and computed tomography and magnetic resonance imaging studies were performed prior to treatment to determine the extent of the tumor.
The tumor was resected by petrosectomy, parotidectomy, and neck dissection in 5 patients. Three times the margins of the histological specimen were free of tumor. Lymph node metastasis in the neck were seen in 5 cases, while distant metastasis did not occur. Two patients underwent primary irradiation, but a postoperative radiation therapy was performed five times. To date, three patients died after one year follow-up.
Carcinoma of the temporal bone is a rare tumor, which can be treated only in case of early diagnosis.
外耳道和中耳癌是一种较为罕见的疾病,尤其多见于患有慢性耳部炎症疾病的患者。
1993年至1994年间,我们治疗了7例患有此类肿瘤的患者,其中6例为鳞状细胞癌,1例可能为腺癌。3例患者的恶性肿瘤发生在耳部根治性腔隙内并导致面瘫。只有2例患者耳部无任何分泌物。除面瘫外,耳部出血性溢液和耳痛是主要症状。1例患者因淋巴结转移出现双侧颈部无痛性肿胀。仅3例患者通过活检确诊,4例患者在乳突切除术后根据切除标本确诊。治疗前进行了血管造影、计算机断层扫描和磁共振成像检查以确定肿瘤范围。
5例患者通过颞骨切除术、腮腺切除术和颈部淋巴结清扫术切除肿瘤。组织学标本的切缘3次均无肿瘤。5例患者出现颈部淋巴结转移,未发生远处转移。2例患者接受了原发灶放疗,但术后放疗进行了5次。截至目前,3例患者在1年随访后死亡。
颞骨癌是一种罕见肿瘤,只有在早期诊断时才能进行治疗。