Hoop Jinger G, Smyth Angela C, Roberts Laura Weiss
Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
Child Adolesc Psychiatr Clin N Am. 2008 Jan;17(1):127-48, x. doi: 10.1016/j.chc.2007.07.003.
Psychiatric research on children and adolescents is ethically justified by the need to reduce the burden that mental illnesses place on young people, their families, and society. Such research must be conducted with careful attention to the ethical principles of beneficence, justice, and respect for persons. Child and adolescent psychiatrists who collaborate on research trials or advise patients and families about research participation should consider nine domains when evaluating the ethical acceptability of particular protocols. These domains include scientific merit and design; expertise, commitment, and integrity; risks and benefits; confidentiality; participant selection and recruitment; informed consent and decisional capacity; incentives; institution and peer/professional review; and data presentation. Special ethical issues in child and adolescent psychiatry research concern the use of randomized, controlled treatment trials; the informed consent process for research involving adolescents; the therapeutic misconception; and conflicts of interest in physician referrals.
儿童和青少年的精神病学研究在伦理上是合理的，因为有必要减轻精神疾病给年轻人及其家庭和社会带来的负担。此类研究必须在进行时认真关注行善、公正和尊重人的伦理原则。参与研究试验或就研究参与向患者及家属提供建议的儿童和青少年精神科医生在评估特定方案的伦理可接受性时应考虑九个领域。这些领域包括科学价值和设计；专业知识、投入和诚信；风险和益处；保密；参与者选择和招募；知情同意和决策能力；激励措施；机构及同行/专业评审；以及数据呈现。儿童和青少年精神病学研究中的特殊伦理问题涉及随机对照治疗试验的使用；涉及青少年的研究的知情同意过程；治疗误解；以及医生转诊中的利益冲突。
