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[颌面及颈部恶性肿瘤放疗后行重建手术患者并发症的免疫预后]

[The immunological prognosis of complications in patients undergoing reconstructive operations after the radiation therapy of malignant tumors of the maxillofacial area and neck].

作者信息

Trufanov V D, Boĭkov A N, Simonova A V, Zandelov V L, Kulakov A V

出版信息

Stomatologiia (Mosk). 1991 Nov-Dec(6):35-7.

PMID:1803649
Abstract

Immunologic studies were carried out in 55 patients with local malignant processes in the maxillofacial area and neck before and after surgery. The patients were divided into 2 groups: group 1 (N = 20) received no specific therapy before surgery, group 2 (n = 35) were administered radiotherapy in a total focal dose of 56-65 Gy before the operation. The findings evidence that radiotherapy augments B and T system immunodeficiency manifestations after surgical stress. Postoperative complications in the patients administered radiotherapy before surgery are due to not only immunodeficiency, but to the initial presence of an infective agent as well. Immunocorrective therapy before and after surgery may be recommended to patients whose immunity parameters are shifted.

摘要

对55例颌面部和颈部局部恶性病变患者在手术前后进行了免疫学研究。患者分为两组:第1组(N = 20)在手术前未接受特殊治疗,第2组(n = 35)在手术前接受了总局部剂量为56 - 65 Gy的放射治疗。研究结果表明,放射治疗会加剧手术应激后B和T系统免疫缺陷表现。术前接受放射治疗的患者术后并发症不仅归因于免疫缺陷,还归因于感染因子的初始存在。对于免疫参数发生改变的患者,可建议在手术前后进行免疫纠正治疗。

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