线粒体一氧化氮合酶活性与呼吸链复合体I的关联
Association of mitochondrial nitric oxide synthase activity with respiratory chain complex I.
作者信息
Parihar Mordhwaj S, Nazarewicz Rafal R, Kincaid Erick, Bringold Urs, Ghafourifar Pedram
机构信息
Department of Surgery, Davis Heart and Lung Research Institute, and Institute of Mitochondrial Biology, The Ohio State University, Columbus, OH, USA.
出版信息
Biochem Biophys Res Commun. 2008 Feb 1;366(1):23-8. doi: 10.1016/j.bbrc.2007.11.056. Epub 2007 Nov 26.
Abstract
The present study shows that rat liver and brain mitochondrial nitric oxide synthase (mtNOS) are functionally associated with mitochondrial respiratory chain complex I. When complex I is activated, mtNOS exerts high activity and generates nitric oxide, whereas inactivation of complex I leads mtNOS to abandon its NOS activity. Functional association of mtNOS with complex I is potentially important in regulating mtNOS activity and mitochondrial functions.
摘要
本研究表明，大鼠肝脏和脑线粒体一氧化氮合酶（mtNOS）在功能上与线粒体呼吸链复合体I相关联。当复合体I被激活时，mtNOS发挥高活性并产生一氧化氮，而复合体I的失活则导致mtNOS丧失其一氧化氮合酶活性。mtNOS与复合体I的功能关联在调节mtNOS活性和线粒体功能方面可能具有重要意义。
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