脑膜炎的化学预防
Chemoprophylaxis of meningitis.
作者信息
Jones D M
机构信息
Manchester Public Health Laboratory, Withington Hospital, UK.
出版信息
Trans R Soc Trop Med Hyg. 1991;85 Suppl 1:44-5. doi: 10.1016/0035-9203(91)90340-5.
Chemoprophylaxis of meningitis caused by Neisseria meningitidis and Haemophilus influenzae may be determined by the epidemiology of transmission, the antibiotic susceptibility patterns of the organisms, and the usage of vaccines. A review of transmission in England distinguishes differences in sporadic and cluster meningococcal infections. Because of resistance to sulphadiazine, rifampicin and ciprofloxacin are prophylactic agents of choice. Vaccination can be a useful adjunct to antibiotic prophylaxis. Prophylaxis for meningitis due to H. influenzae type b can be provided by rifampicin and vaccination can also be an adjunct to antibiotic prophylaxis.
对脑膜炎奈瑟菌和流感嗜血杆菌引起的脑膜炎进行化学预防，可依据传播流行病学、病原体的抗生素敏感性模式以及疫苗的使用情况来确定。对英国传播情况的回顾区分了散发性和聚集性脑膜炎球菌感染的差异。由于对磺胺嘧啶耐药，利福平和环丙沙星是首选的预防药物。疫苗接种可以作为抗生素预防的有益辅助手段。针对b型流感嗜血杆菌引起的脑膜炎，利福平可提供预防作用，疫苗接种也可作为抗生素预防的辅助手段。
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