创伤后应激障碍退伍军人血浆促肾上腺皮质激素释放激素水平升高。
Elevated plasma corticotrophin-releasing hormone levels in veterans with posttraumatic stress disorder.
作者信息
de Kloet C S, Vermetten E, Geuze E, Lentjes E G W M, Heijnen C J, Stalla G K, Westenberg H G M
机构信息
Altrecht Institute for Mental Health Care, Zeist, The Netherlands.
出版信息
Prog Brain Res. 2008;167:287-91. doi: 10.1016/S0079-6123(07)67025-3.
Posttraumatic stress disorder (PTSD) is associated with alterations in corticotrophin-releasing hormone (CRH) secretion. Plasma CRH levels, which are easily acquired, might serve as a predictor of hypothalamic CRH levels. Assessment of plasma CRH, adrenocorticotrophin hormone (ACTH), and cortisol levels in 31 veterans with PTSD, 30 traumatized veterans without PTSD matched on age, year, and region of deployment (traumacontrols), and 28 age-matched healthy controls (HCs) was carried out. Plasma CRH levels were higher in PTSD patients compared to both HCs (p=0.005) and traumacontrols (p=0.007). This led to our conclusion, that elevated plasma CRH levels are specifically related to PTSD and not to exposure to traumatic stress during deployment.
创伤后应激障碍（PTSD）与促肾上腺皮质激素释放激素（CRH）分泌的改变有关。易于获取的血浆CRH水平可能可作为下丘脑CRH水平的预测指标。对31名患有PTSD的退伍军人、30名年龄、服役年份和部署地区相匹配的未患PTSD的创伤退伍军人（创伤对照组）以及28名年龄匹配的健康对照者（HCs）的血浆CRH、促肾上腺皮质激素（ACTH）和皮质醇水平进行了评估。与HCs（p = 0.005）和创伤对照组（p = 0.007）相比，PTSD患者的血浆CRH水平更高。由此我们得出结论，血浆CRH水平升高与PTSD具体相关，而非与部署期间遭受创伤性应激有关。
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