Int J Cardiol. 2009 Feb 6;132(1):138-40. doi: 10.1016/j.ijcard.2007.07.145. Epub 2007 Nov 26.
Omega-3 polyunsaturated fatty acids (omega 3-PUFAs) from fish oil modulate various ion channels, including the L-type calcium current (I(Ca,L)). As a result, fish oil shortens the cardiac action potential and may cause a loss of the dome of the action potential (AP). Under conditions of increased preexisting heterogeneity in repolarization this may aggravate dispersion in action potential duration. We isolated ventricular myocytes of explanted hearts from patients with cardiomyopathy at the time of cardiac transplantation, and characterized spike-and-dome morphology in the presence of acutely administered fish oil. Fish oil omega 3-PUFA eicosapentaenoic acid (EPA), but not the control omega 9-PUFA oleic acid (OA), curtails the AP-dome in a heterogeneous manner and may even result in loss of the AP-dome in some but not all myocytes.
鱼油中的ω-3 多不饱和脂肪酸（ω-3-PUFA）可调节多种离子通道，包括 L 型钙电流（I(Ca,L)）。因此，鱼油会缩短心脏动作电位，并可能导致动作电位（AP）的峰消失。在复极预先存在的异质性增加的情况下，这可能会导致动作电位持续时间的离散度增加。我们从心脏移植时患有心肌病的患者的心脏中分离出心室肌细胞，并在急性给予鱼油的情况下对尖峰和峰的形态进行了特征描述。鱼油 ω-3-PUFA 二十碳五烯酸（EPA），而不是对照 ω-9-PUFA 油酸（OA），以不均匀的方式缩短 AP 峰，甚至在一些但不是所有的心肌细胞中导致 AP 峰消失。
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