Hoekema A, Doff M H J, de Bont L G M, van der Hoeven J H, Wijkstra P J, Pasma H R, Stegenga B
Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30.001, 9700 RB, Groningen, The Netherlands.
J Dent Res. 2007 Dec;86(12):1181-6. doi: 10.1177/154405910708601208.
Oral appliance therapy is an alternative to continuous positive airway pressure (CPAP) for treating the obstructive sleep apnea-hypopnea syndrome. However, the ability to pre-select suitable candidates for either treatment is limited. The aim of this study was to assess the value of relevant variables that can predict the outcome of oral appliance and CPAP therapy. Fifty-one patients treated with oral appliance therapy and 52 patients treated with CPAP were included. Relevant clinical, polysomnographic, and cephalometric variables were determined at baseline. The predictive value of variables for treatment outcome was evaluated in univariate and multivariate analyses. The outcome of oral appliance therapy was favorable, especially in less obese patients with milder sleep apnea and with certain craniofacial characteristics (mandibular retrognathism in particular). Neither univariate nor multivariate analyses yielded variables that reliably predicted the outcome of CPAP. We conclude that the variables found in this study are valuable for pre-selecting suitable candidates for oral-appliance therapy.
口腔矫治器疗法是治疗阻塞性睡眠呼吸暂停低通气综合征的一种替代持续气道正压通气（CPAP）的方法。然而，预先选择适合这两种治疗方法的患者的能力有限。本研究的目的是评估能够预测口腔矫治器和CPAP治疗效果的相关变量的价值。纳入了51例接受口腔矫治器治疗的患者和52例接受CPAP治疗的患者。在基线时确定相关的临床、多导睡眠图和头影测量变量。在单因素和多因素分析中评估变量对治疗效果的预测价值。口腔矫治器治疗的效果良好，尤其是在肥胖程度较低、睡眠呼吸暂停较轻且具有某些颅面特征（特别是下颌后缩）的患者中。单因素和多因素分析均未得出能够可靠预测CPAP治疗效果的变量。我们得出结论，本研究中发现的变量对于预先选择适合口腔矫治器治疗的患者具有重要价值。
