小鼠12号染色体上的一个基因组片段决定上颌骨生长。

A genome segment on mouse chromosome 12 determines maxillary growth.

作者信息

Oh J, Wang C J, Poole M, Kim E, Davis R C, Nishimura I, Pae E-K

机构信息

Section of Orthodontics, UCLA School of Dentistry, 43-091 Center for the Health Sciences, Box 951668, Los Angeles, CA 90095-1668, USA.

出版信息

J Dent Res. 2007 Dec;86(12):1203-6. doi: 10.1177/154405910708601212.

DOI:10.1177/154405910708601212

PMID:18037656

Abstract

The primary and modifier genes that regulate normal maxillofacial development are unknown. Previous quantitative trait locus (QTL) analyses using the F2 progeny of 2 mouse strains, DBA/2J (short snout/wide face) and C57BL/6J (long snout/narrow face), revealed a significant logarithm-of-odds (LOD) score for snout length on mouse chromosome 12 at 44 centimorgan (cM). We further sought to validate this locus contributing to anterior-posterior dimensions of the upper mid-face at the D12Mit7 marker in a 44-centimorgan portion of chromosome 12. Congenic mice carrying introgressed DNA from DBA/2J on a C57BL/6J background were selected for submental vertex cephalometric imaging. Results confirmed QTLs, determining that short snout length (P < 0.05) and face width relative to snout length (P < 0.01) were present in the 44-cM region of chromosome 12. We conclude that one or more genes contributing to the shape of the maxillary complex are located near 44 cM of mouse chromosome 12.

摘要

调控正常颌面发育的主基因和修饰基因尚不清楚。先前使用两种小鼠品系DBA/2J（短鼻/宽脸）和C57BL/6J（长鼻/窄脸）的F2后代进行的数量性状基因座（QTL）分析显示，在小鼠12号染色体上44厘摩（cM）处，鼻长的对数优势（LOD）得分显著。我们进一步试图在12号染色体44厘摩区域的D12Mit7标记处验证这一影响上颌中部前后尺寸的基因座。选择在C57BL/6J背景上携带来自DBA/2J渗入DNA的近交系小鼠进行颏下顶点头颅测量成像。结果证实了数量性状基因座，确定在12号染色体的44厘摩区域存在短鼻长（P < 0.05）和相对于鼻长的脸宽（P < 0.01）。我们得出结论，一个或多个影响上颌复合体形状的基因位于小鼠12号染色体44厘摩附近。