Blanco E, Pilgrim C, Vazquez R, Jirikowski G F
Departamento de Anatomía e Histología Humanas, Facultad de Medicina, Universidad de Salamanca, Spain.
Acta Histochem. 1991;91(2):165-72. doi: 10.1016/S0065-1281(11)80272-2.
Increased numbers of oxytocin-immunoreactive perivascular neurons have been shown to occur in the preoptic region and lateral hypothalamus of female rats around parturition. In the present study, electronmicroscopical immunocytochemistry and morphometry were used to examine such perivascular oxytocinergic neurons as well as those in the classical magnocellular nuclei in late pregnant and lactating rats. In 22 d pregnant animals and in rats killed after 2 d of lactation, numerous oxytocinergic neurons were found in direct apposition to the outer basement membrane of arterioles, venules, and capillaries. The distance between immunoreactive neurons and blood vessels was significantly lower in these animals than in 9 d lactating rats and in ovariectomized controls. It is likely that, around parturition, oxytocinergic perivascular neurons are uncovered by active retraction of glial elements. This plasticity is perhaps facilitated by changing hormonal conditions around parturition. The observed changes seem to be transitory and might reflect altered secretory properties of perivascular oxytocinergic neurons.
研究表明，在分娩前后的雌性大鼠视前区和下丘脑外侧，催产素免疫反应性血管周围神经元数量增加。在本研究中，采用电子显微镜免疫细胞化学和形态计量学方法，对妊娠晚期和哺乳期大鼠的此类血管周围催产素能神经元以及经典大细胞核中的神经元进行了检测。在怀孕22天的动物和哺乳2天后处死的大鼠中，发现大量催产素能神经元直接贴附于小动脉、小静脉和毛细血管的外基底膜。与9天哺乳期大鼠和去卵巢对照组相比，这些动物中免疫反应性神经元与血管之间的距离显著缩短。分娩前后，胶质细胞成分的主动回缩可能使血管周围催产素能神经元暴露出来。分娩前后激素条件的变化可能促进了这种可塑性。观察到的变化似乎是暂时的，可能反映了血管周围催产素能神经元分泌特性的改变。
