Park H-M, Hwang D-N, Kang B-T, Jung D-I, Song G-S, Lee S-J, Yhee J-Y, Yu C-H, Doster A R, Sur J-H
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Kwangjin-Ku, Seoul, Korea.
Vet Pathol. 2007 Nov;44(6):921-3. doi: 10.1354/vp.44-6-921.
We describe a 10-month-old, intact female American Cocker Spaniel with pulmonary lymphomatoid granulomatosis (PLG). On clinical examination, this dog presented with nonproductive dry cough, serous nasal discharge, dyspnea, and lack of appetite. Radiography showed a consolidated lesion in the left cranial lung lobe. Histopathologic examination showed a mixed population of atypical lymphoid cells that had infiltrated into the pulmonary blood vessels angiocentrically. The lymphocytes were CD3 positive, consistent with a pan-T-cell phenotype. The lymphoid cells in the lesion were also positive for CD20cy and CD79a, indicative of the presence of B cells. We also observed large Reed-Sternberg-like cells that were positive for CD15 and CD30, similar to observations in human pulmonary Hodgkin's disease (PHD). In conclusion, canine PLG in this Cocker Spaniel was associated with B and T cells, which is first identified in a case of canine PLG. It was histopathologically similar to human lymphomatoid granulomatosis and immunophenotypically similar to human PHD.
我们描述了一只10个月大、未绝育的雌性美国可卡犬，患有肺淋巴瘤样肉芽肿病（PLG）。临床检查时，这只犬表现为干咳无痰、浆液性鼻液、呼吸困难和食欲不振。放射检查显示左肺前叶有一个实变病灶。组织病理学检查显示有一群非典型淋巴细胞混合，呈血管中心性浸润到肺血管中。淋巴细胞CD3呈阳性，符合泛T细胞表型。病灶中的淋巴细胞CD20cy和CD79a也呈阳性，表明存在B细胞。我们还观察到大型里德-施特恩伯格样细胞，CD15和CD30呈阳性，这与人类肺霍奇金病（PHD）中的观察结果相似。总之，这只可卡犬的犬PLG与B细胞和T细胞有关，这是在一例犬PLG病例中首次发现的。它在组织病理学上与人类淋巴瘤样肉芽肿病相似，在免疫表型上与人类PHD相似。
