一系列双阳离子杀锥虫药物在酿酒酵母中的微小诱变作用。
Petite mutagenesis in Saccharomyces cerevisiae by a series of bis-cationic trypanocidal drugs.
作者信息
Ferguson L R, Sundberg R J
机构信息
Cancer Research Laboratory, University of Auckland Medical School, New Zealand.
出版信息
Antimicrob Agents Chemother. 1991 Nov;35(11):2318-21. doi: 10.1128/AAC.35.11.2318.
Abstract
A group of bis-cationic imidazo[1,2-a]pyridinium salts and related compounds, some of which exhibit in vivo trypanocidal activity, have been investigated for induction of petite mutagenesis in Saccharomyces cerevisiae. All of the compounds which are active trypanocides induce mutagenesis. There appears to be a correlation between trypanocidal activity and mutagenic activity which may have its structural origin in the spatial separation of the cationic centers.
摘要
一组双阳离子咪唑并[1,2 - a]吡啶鎓盐及相关化合物，其中一些在体内表现出杀锥虫活性，已针对其在酿酒酵母中诱导小菌落突变进行了研究。所有具有杀锥虫活性的化合物都会诱导突变。杀锥虫活性和诱变活性之间似乎存在相关性，这可能在结构上源于阳离子中心的空间分离。
相似文献
1
Petite mutagenesis in Saccharomyces cerevisiae by a series of bis-cationic trypanocidal drugs.一系列双阳离子杀锥虫药物在酿酒酵母中的微小诱变作用。
Antimicrob Agents Chemother. 1991 Nov;35(11):2318-21. doi: 10.1128/AAC.35.11.2318.
2
'Petite' mutagenesis by anticancer drugs in Saccharomyces cerevisiae.抗癌药物在酿酒酵母中引发的“微小”诱变
Eur J Cancer Clin Oncol. 1988 Apr;24(4):591-6. doi: 10.1016/0277-5379(88)90286-6.
3
Petite induction in yeast, Saccharomyces cerevisiae, by phenanthridinium compounds: promotive effects of propidium iodide on mutagenesis by ethidium bromide or 8-deaminoethidium chloride.菲啶鎓化合物对酿酒酵母（Saccharomyces cerevisiae）的微小诱导作用：碘化丙啶对溴化乙锭或氯化8-脱氨基乙锭诱变的促进作用。
Chem Pharm Bull (Tokyo). 1986 Apr;34(4):1735-9. doi: 10.1248/cpb.34.1735.
4
Biogenesis of mitochondria. 43. A comparative study of petite induction and inhibition of mitochondrial DNA replication in yeast by ethidium bromide and berenil.线粒体的生物发生。43. 溴化乙锭和贝尼尔对酵母中微小菌落诱导及线粒体DNA复制抑制的比较研究。
Mol Gen Genet. 1975 Dec 9;141(4):291-304. doi: 10.1007/BF00331451.
5
Apparent changes in structure-activity relationships for antimitochondrial effects of 9-anilinoacridines according to Saccharomyces cerevisiae strain and methodology.根据酿酒酵母菌株和方法，9-苯胺基吖啶抗线粒体效应的构效关系的明显变化。
Mutat Res. 1984 Jun;136(3):223-31. doi: 10.1016/0165-1218(84)90056-9.
6
Induction of the cytoplasmic 'petite' mutation by chemical and physical agents in Saccharomyces cerevisiae.化学和物理因子诱导酿酒酵母细胞质“小菌落”突变
Mutat Res. 1992 Jan;265(1):103-48. doi: 10.1016/0027-5107(92)90042-z.
7
The mutagenic effects of diacridines and diquinolines in microbial systems.二吖啶和二喹啉在微生物系统中的诱变作用。
Mutat Res. 1990 Oct;232(2):337-43. doi: 10.1016/0027-5107(90)90140-y.
8
Effect of aspirin on mitochondrial mutagens in Saccharomyces cerevisiae.阿司匹林对酿酒酵母中线粒体诱变剂的影响。
Mol Gen Genet. 1984;194(1-2):299-302. doi: 10.1007/BF00383531.
9
The genetic activity of N6-hydroxyadenine and 2-amino-N6-hydroxyadenine in Escherichia coli, Salmonella typhimurium and Saccharomyces cerevisiae.N6-羟基腺嘌呤和2-氨基-N6-羟基腺嘌呤在大肠杆菌、鼠伤寒沙门氏菌和酿酒酵母中的遗传活性。
Mutat Res. 1991 Aug;253(1):33-46. doi: 10.1016/0165-1161(91)90343-7.
10
Toxicity, mutagenicity and transport in Saccharomyces cerevisiae of three popular DNA intercalating fluorescent dyes.三种常见的DNA嵌入荧光染料在酿酒酵母中的毒性、致突变性及转运
Yeast. 2015 Sep;32(9):595-606. doi: 10.1002/yea.3081. Epub 2015 Jul 21.
引用本文的文献
1
Activity of diimidazoline amides against African trypanosomiasis.二咪唑啉酰胺对非洲锥虫病的活性。
Bioorg Med Chem Lett. 2014 Feb 1;24(3):944-8. doi: 10.1016/j.bmcl.2013.12.064. Epub 2013 Dec 22.
2
Microarray analysis of the in vivo sequence preferences of a minor groove binding drug.小沟结合药物体内序列偏好性的微阵列分析
BMC Genomics. 2008 Jan 23;9:32. doi: 10.1186/1471-2164-9-32.
3
A cytotoxicity assay for evaluation of candidate anti-Pneumocystis carinii agents.一种用于评估候选抗卡氏肺孢子虫药物的细胞毒性测定法。
Antimicrob Agents Chemother. 1997 Feb;41(2):379-84. doi: 10.1128/AAC.41.2.379.
4
Guanylhydrazones in therapy of Pneumocystis carinii pneumonia in immunosuppressed rats.胍基腙在免疫抑制大鼠卡氏肺孢子虫肺炎治疗中的应用
Antimicrob Agents Chemother. 1994 Nov;38(11):2572-6. doi: 10.1128/AAC.38.11.2572.
本文引用的文献
1
Induction of the respiration-deficient mutation in yeast by various synthetic dyes.多种合成染料诱导酵母呼吸缺陷型突变
Science. 1959 Oct 30;130(3383):1188-9. doi: 10.1126/science.130.3383.1188-a.
2
Existence of an extended series of antitumor compounds which bind to deoxyribonucleic acid by nonintercalative means.存在一系列通过非嵌入方式与脱氧核糖核酸结合的抗肿瘤化合物。
Biochemistry. 1980 Mar 18;19(6):1101-6. doi: 10.1021/bi00547a009.
3
Interactions of antitumor drugs with natural DNA: 1H NMR study of binding mode and kinetics.抗肿瘤药物与天然DNA的相互作用：结合模式和动力学的1H NMR研究
J Med Chem. 1984 Apr;27(4):450-65. doi: 10.1021/jm00370a007.
4
Antitumor phthalanilides active in acute and chronic Trypanosoma brucei brucei murine infections.对布氏布氏锥虫急性和慢性鼠感染有效的抗肿瘤邻苯二甲酰亚胺类化合物。
Am J Trop Med Hyg. 1984 Sep;33(5):845-50. doi: 10.4269/ajtmh.1984.33.845.
5
Apparent changes in structure-activity relationships for antimitochondrial effects of 9-anilinoacridines according to Saccharomyces cerevisiae strain and methodology.根据酿酒酵母菌株和方法，9-苯胺基吖啶抗线粒体效应的构效关系的明显变化。
Mutat Res. 1984 Jun;136(3):223-31. doi: 10.1016/0165-1218(84)90056-9.
6
Intensive cytoreductive regimen and autologous bone marrow transplantation in leukemia. Present status and the future. A review.白血病的强化细胞减灭方案及自体骨髓移植。现状与未来。综述
Eur J Cancer Clin Oncol. 1983 Aug;19(8):1043-52. doi: 10.1016/0277-5379(83)90027-5.
7
Potential antitumour agents. X. Bisquaternary salts.潜在的抗肿瘤药物。X. 双季铵盐。
J Med Chem. 1969 Mar;12(2):199-206. doi: 10.1021/jm00302a001.
8
Ethidium bromide induced mutation of yeast mitochondria: complete transformation of cells into respiratory deficient non-chromosomal "petites".溴化乙锭诱导酵母线粒体突变：细胞完全转变为呼吸缺陷型非染色体“小菌落”。
Biochem Biophys Res Commun. 1968 Feb 15;30(3):232-9. doi: 10.1016/0006-291x(68)90440-3.
9
Induction of respiration deficient mutants in Saccharomyces cerevisiae by berenil. I. Berenil, a novel, non-intercalating mutagen.贝尼尔诱导酿酒酵母呼吸缺陷型突变体。I. 贝尼尔，一种新型非嵌入诱变剂。
Mol Gen Genet. 1973 Mar 19;121(4):285-94. doi: 10.1007/BF00433228.
10
A yeast strain for visual screening for the two reciprocal products of mitotic crossing over.一种用于对有丝分裂交换的两种相互产物进行视觉筛选的酵母菌株。
Mutat Res. 1973 Oct;21(5):263-9.
Zotero 插件