玻璃体内注射曲安奈德治疗视网膜中央静脉阻塞所致的浆液性黄斑脱离。

Intravitreal triamcinolone acetonide for treatment of serous macular detachment in central retinal vein occlusion.

作者信息

Karacorlu Murat, Karacorlu Serra Arf, Ozdemir Hakan, Senturk Fevzi

机构信息

Istanbul Retina Institute, Inc., Istanbul, Turkey.

出版信息

Retina. 2007 Oct;27(8):1026-30. doi: 10.1097/IAE.0b013e3180645905.

DOI:10.1097/IAE.0b013e3180645905

PMID:18040239

Abstract

PURPOSE

To evaluate the effect of intravitreal triamcinolone acetonide (IVTA) treatment on serous macular detachment in patients with central retinal vein occlusion (CRVO).

METHODS

Ten eyes of 10 patients with CRVO (6 men and 4 women; age range, 54-78 years) made up the study population. The eligibility criteria for this study included clinically and angiographically detectable cystoid macular edema (CME) in which the presence of serous macular detachment was documented by optical coherence tomography (OCT). After IVTA (4 mg/0.1 mL) injection, visual and anatomical responses were observed.

RESULTS

In all eyes, after IVTA injection, CME and serous macular detachment regressed. At 3 months and 6 months, CME and serous macular detachment had recurred in 4 (40%) and 5 eyes (50%), respectively. Patients with recurrence were retreated. No eyes lost vision at 1 month, and all eyes had improvement. At 3 months, no eyes had lost vision from baseline, and 7 eyes (70%) had improvement. At 6 months, again no eyes had lost vision from baseline, and 6 eyes (60%) maintained improved visual acuity.

CONCLUSIONS

Our study shows that IVTA is effective treatment for serous macular detachment in patients with CRVO.

摘要

目的

评估玻璃体内注射曲安奈德（IVTA）治疗视网膜中央静脉阻塞（CRVO）患者浆液性黄斑脱离的效果。

方法

10例CRVO患者（6例男性，4例女性；年龄范围54 - 78岁）的10只眼构成研究人群。本研究的纳入标准包括临床和血管造影可检测到的黄斑囊样水肿（CME），其中光学相干断层扫描（OCT）记录有浆液性黄斑脱离。注射IVTA（4 mg/0.1 mL）后，观察视力和解剖学反应。

结果

所有眼在注射IVTA后，CME和浆液性黄斑脱离均消退。在3个月和6个月时，分别有4只眼（40%）和5只眼（50%）出现CME和浆液性黄斑脱离复发。复发患者接受再次治疗。1个月时无眼视力丧失，所有眼均有改善。3个月时，无眼视力较基线下降，7只眼（70%）视力改善。6个月时，同样无眼视力较基线下降，6只眼（60%）维持视力改善。