Ozkaya Abdullah, Celik Ugur, Alkin Zeynep, Faiz Turan Miray, Yazici Ahmet Taylan, Demirok Ahmet
Beyoglu Eye Training and Research Hospital, Bereketzade Camii Sok., Kuledibi, Beyoglu, 34421 Istanbul, Turkey.
Beyoglu Eye Training and Research Hospital, Bereketzade Camii Sok., Kuledibi, Beyoglu, 34421 Istanbul, Turkey ; Department of Ophthalmology, Medeniyet University, 34700 Istanbul, Turkey.
ISRN Ophthalmol. 2013 Dec 19;2013:141279. doi: 10.1155/2013/141279. eCollection 2013.
Purpose. To compare the efficacy of intravitreal triamcinolone (IVT) and intravitreal bevacizumab (IVB), both combined with grid laser photocoagulation (GLP) for macular edema (ME) secondary to branch retinal vein occlusion (BRVO). Methods. Retrospective, comparative study. The newly diagnosed patients with ME secondary to BRVO who were treated with IVT and GLP or IVB and GLP were included. The main outcome measures were changed in the best corrected visual acuity (BCVA) and central retinal thickness (CRT) from the baseline to month 24. Results. Ninety-nine eyes of 99 patients were included. The change in BCVA was not statistically different in any time points between the two groups (P > 0.05, for all). The change in CRT was not statistically different in any time points between the two groups (P > 0.05, for all). The mean number of injections at month 24 was 2.38 ± 1.06 in the IVT+GLP group and 4.17 ± 1.30 in the IVB+GLP group (P = 0.0001). The need for cataract surgery (P = 0.01) and secondary glaucoma (P = 0.03) occurrence were more common in IVT group. Conclusion. Both treatment modalities were effective in the treatment of ME secondary to BRVO. The number of injections was significantly lower in the IVT group than in the IVB group; however cataract and secondary glaucoma were more frequent in the IVT+GLP group than in the IVB+GLP group.
目的。比较玻璃体内注射曲安奈德（IVT）和玻璃体内注射贝伐单抗（IVB）联合格栅激光光凝（GLP）治疗视网膜分支静脉阻塞（BRVO）继发黄斑水肿（ME）的疗效。方法。回顾性比较研究。纳入新诊断的BRVO继发ME且接受IVT联合GLP或IVB联合GLP治疗的患者。主要观察指标为从基线到第24个月最佳矫正视力（BCVA）和中心视网膜厚度（CRT）的变化。结果。纳入99例患者的99只眼。两组在任何时间点的BCVA变化均无统计学差异（所有P>0.05）。两组在任何时间点的CRT变化均无统计学差异（所有P>0.05）。IVT+GLP组在第24个月时的平均注射次数为2.38±1.06次，IVB+GLP组为4.17±1.30次（P=0.0001）。IVT组白内障手术需求（P=0.01）和继发性青光眼发生率（P=0.03）更高。结论。两种治疗方式对BRVO继发ME均有效。IVT组的注射次数显著低于IVB组；然而，IVT+GLP组白内障和继发性青光眼的发生率高于IVB+GLP组。
