Giménez-Roldán S
Servicio de Neurología, Hospital General Gregorio Marañón, Madrid.
Arch Neurobiol (Madr). 1991 Sep-Oct;54(5):198-205.
Except in Wilson's disease, few secondary dystonias are susceptible to benefit from an aetiological treatment. The somatic distribution of dystonia often determines the therapeutic strategy. Thus, stereotactic surgery may be the treatment of choice for hemidystonia while anticholinergic medication may alleviate generalized dystonia, particularly in childhood. Finally, local infiltrations of botulinum toxin are particularly useful for various forms of local and segmental dystonia. Certain subsyndromes as myoclonic dystonia, levodopa sensitive dystonia and paroxysmal choreoathetosis may benefit from relatively specific treatment strategies.
除威尔逊病外,很少有继发性肌张力障碍能从病因治疗中获益。肌张力障碍的躯体分布常决定治疗策略。因此,立体定向手术可能是偏侧肌张力障碍的首选治疗方法,而抗胆碱能药物可缓解全身性肌张力障碍,尤其是在儿童中。最后,肉毒杆菌毒素局部注射对各种局部和节段性肌张力障碍特别有用。某些亚综合征,如肌阵挛性肌张力障碍、左旋多巴敏感型肌张力障碍和阵发性舞蹈手足徐动症,可能从相对特异的治疗策略中获益。