肌张力障碍

The dystonias.

作者信息

Markham C H

机构信息

Department of Neurology, UCLA School of Medicine.

出版信息

Curr Opin Neurol Neurosurg. 1992 Jun;5(3):301-7.

PMID:1623256

Abstract

The various dystonias have been found in at least five different hereditary backgrounds. The gene responsible for one of the dystonias, idiopathic torsion dystonia (ITD), lies on chromosome 9q32-34, with flanking markers now 1-2 cM apart. Magnetic resonance imaging and computerized tomography (CT) abnormalities in the basal ganglia, especially in the putamen, are found in many secondary dystonias. Botulinum toxin therapy is proving very useful in the treatment of focal dystonias.

摘要

已发现至少五种不同遗传背景下存在各种肌张力障碍。其中一种肌张力障碍，即特发性扭转性肌张力障碍（ITD）的致病基因位于9号染色体的q32 - 34区域，其侧翼标记现在相距1 - 2厘摩。在许多继发性肌张力障碍中发现基底神经节，尤其是壳核存在磁共振成像和计算机断层扫描（CT）异常。肉毒杆菌毒素疗法在治疗局灶性肌张力障碍方面已证明非常有用。