Paradowski A, Rózga M, Nawrocka E, Siemion I Z
Department of Physiology, Pomeranian Medical Academy, Wrocław.
Arch Immunol Ther Exp (Warsz). 1991;39(1-2):153-7.
The performed studies dealt with the effect of tuftsin (tetrapeptide Thr-Lys-Pro-Arg), a stimulator of many components of immunological reactions, exerted on histamine concentration in lungs, kidneys, liver, duodenal wall and arterial blood of guinea-pigs. Tuftsin was given intraperitoneally, in a single dose (0.5 and 1.0 mg/kg) or three times at one-hour intervals (1.0 mg/kg). It has been revealed that tuftsin alters the histamine concentration in tissues of guinea-pigs by lowering it in lungs, and by elevating it in kidneys and liver, in the latter insignificantly.
