促吞噬素部分序列对豚鼠和大鼠组织中组胺水平的影响。

The influence of tuftsin partial sequences on histamine level in guinea pig and rat tissues.

作者信息

Paradowski A, Rózga M, Wronowska G, Nawrocka-Bolewska E, Siemion I Z

机构信息

Department of Physiology, Pomeranian Medical Academy, Szczecin, Poland.

出版信息

Arch Immunol Ther Exp (Warsz). 1992;40(3-4):207-12.

PMID:1300985

Abstract

We investigated the influence of tuftsin partial sequences (Thr-Lys, Lys-Pro, Lys-Pro-Arg and Pro-Arg) on histamine concentration in selected tissues (lungs, kidneys, liver, duodenal wall and arterial blood) of guinea-pigs and rats. The peptides were administered in 1 mg/kg dose intravenously (single dose) or intraperitoneally (single dose or three doses at one-hour intervals). Histamine concentration was determined spectrofluorimetrically. Tissues used in the determination were taken 1 hour after the last injection. It was found that Pro-Arg and Lys-Pro-Arg (similarly to tuftsin), lower histamine concentration in lungs, and elevate it in kidneys.

摘要

我们研究了促吞噬素部分序列（苏氨酸-赖氨酸、赖氨酸-脯氨酸、赖氨酸-脯氨酸-精氨酸和脯氨酸-精氨酸）对豚鼠和大鼠特定组织（肺、肾、肝、十二指肠壁和动脉血）中组胺浓度的影响。这些肽以1毫克/千克的剂量静脉注射（单剂量）或腹腔注射（单剂量或每隔一小时注射三剂）。通过荧光分光光度法测定组胺浓度。测定中使用的组织在最后一次注射后1小时采集。结果发现，脯氨酸-精氨酸和赖氨酸-脯氨酸-精氨酸（与促吞噬素类似）可降低肺中的组胺浓度，并提高肾中的组胺浓度。