Oakes L, Anseline M, Carlton J
Royal Newcastle Hospital, New South Wales.
Aust Clin Rev. 1991;11(4):138-42.
The introduction of Total Parenteral Nutrition (TPN) in the treatment of malnourished patients with unusable gastrointestinal tracts has become commonplace throughout the world. However there are significant metabolic (4.2 to 7.7%) and septic (7 to 27%) complications associated with this therapy. In 1984 a TPN committee was formed at Royal Newcastle Hospital and a TPN nurse was appointed. This series documents the use of TPN at Royal Newcastle Hospital from August 1984 to July 1989. There were 251 patients who received TPN, representing 3422 days of TPN. The primary catheter sepsis rate was 10.4% at the commencement of the series and decreased appreciably to 3.2%. The formation of the TPN committee and the appointment of a TPN nurse have represented a considerable cost in time and money but this action has been justified by the drop in the sepsis rate resulting in a decrease in morbidity and mortality associated with TPN.
全胃肠外营养（TPN）用于治疗胃肠道功能不可用的营养不良患者，在全世界已变得很普遍。然而，这种治疗方法存在显著的代谢并发症（4.2%至7.7%）和感染并发症（7%至27%）。1984年，皇家纽卡斯尔医院成立了一个TPN委员会，并任命了一名TPN护士。本系列记录了1984年8月至1989年7月皇家纽卡斯尔医院使用TPN的情况。有251名患者接受了TPN治疗，累计TPN治疗天数达3422天。该系列开始时，原发性导管败血症发生率为10.4%，显著下降至3.2%。TPN委员会的组建和TPN护士的任命在时间和金钱上耗费巨大，但败血症发生率的下降证明了这一举措的合理性，从而降低了与TPN相关的发病率和死亡率。
