Carnero Pardo C, Sáez-Zea C, Montiel Navarro L, Del Sazo P, Feria Vilar I, Pérez Navarro M J, Ruiz Jiménez J, Vilchez Carrillo R, Montoro Ríos M T
Servicio de Neurología. Hospital Universitario Virgen de las Nieves. Granada.
Neurologia. 2007 Dec;22(10):860-9.
The recently developed Phototest is a simple, easy and very brief (<3 minutes) test with theoretical advantages over available dementia screening tests. Our objective was to evaluate its diagnostic accuracy under routine clinical conditions.
A phase II cross-sectional validation study of diagnostic tests was performed in a sample of 308 patients referred to a general neurology department and in a group of 70 healthy individuals. The diagnostic accuracy (DA) of the Phototest was assessed and compared with that of the Eurotest and a verbal fluency test (VFT) in relation to the clinical diagnosis of dementia (DEM) and cognitive impairment (CI) by calculating the area under the ROC curve (aROC) and determining Sensitivity (Se), Specificity (Sp) and likelihood ratios.
The total sample comprised 225 subjects without CI (NOR), 58 with CI and without DEM and 95 with DEM. Phototest results showed a normal distribution in NOR subjects (33.4 +/- 3.9 [mean +/- standard desviation]) and were not influenced by educational variables. The DA of the Phototest for DEM and CI (0.95 +/- 0.01 [aRO C+/- Se]) was similar to that of the Eurotest and higher for both tests than that of the VFT. The cutoff points of 25/26 for DEM (Se=0.88 [0.80-0.94], Sp=0.90 [0.86- 0.93]) and 28/29 for CI (Se=0.90 [0.84-0.94], Sp=0.90 [0.83-0.93]) maximised the sum of Se and Sp.
The Phototest is a very short test of easy application that is applicable to illiterate subjects, uninfluenced by educational variables and useful to identify CI and DEM in routine clinical practice.
最近开发的光测试是一种简单、易行且非常简短（<3分钟）的测试，理论上优于现有的痴呆筛查测试。我们的目的是评估其在常规临床条件下的诊断准确性。
在308名转诊至普通神经科的患者样本和70名健康个体中进行了一项诊断测试的II期横断面验证研究。通过计算ROC曲线下面积（aROC）并确定敏感性（Se）、特异性（Sp）和似然比，评估了光测试的诊断准确性（DA），并与欧洲测试和语言流畅性测试（VFT）在痴呆（DEM）和认知障碍（CI）的临床诊断方面进行了比较。
总样本包括225名无CI（NOR）的受试者、58名有CI但无DEM的受试者和95名有DEM的受试者。光测试结果在NOR受试者中呈正态分布（33.4 +/- 3.9 [平均值 +/- 标准差]），且不受教育变量影响。光测试对DEM和CI的DA（0.95 +/- 0.01 [aRO C+/- Se]）与欧洲测试相似，且这两种测试均高于VFT。DEM的截断点为25/26（Se = 0.88 [0.80 - 0.94]，Sp = 0.90 [0.86 - 0.93]），CI的截断点为28/29（Se = 0.90 [0.84 - 0.94]，Sp = 0.90 [0.83 - 0.93]）时，Se和Sp之和最大。
光测试是一种应用简便的非常简短的测试，适用于文盲受试者，不受教育变量影响，在常规临床实践中有助于识别CI和DEM。
