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[氙气——理想的麻醉剂?]

[Xenon--the ideal anaesthetic agent?].

作者信息

Bein Berthold, Höcker Jan, Scholz Jens

机构信息

Klinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Schleswig-Holstein, Campus Kiel.

出版信息

Anasthesiol Intensivmed Notfallmed Schmerzther. 2007 Nov;42(11):784-91. doi: 10.1055/s-2007-1003591.

DOI:10.1055/s-2007-1003591
PMID:18040933
Abstract

The noble gas xenon, besides its anaesthetic and analgesic properties, shows many characteristics of an ideal anaesthetic agent. However, due to high production costs, its application is limited In daily clinical routine. Recent studies suggested not only outstanding haemodynamic stability and rapid emergence from anaesthesia, but also xenon's capacity to mediate protection against ischaemic damage in various organs and tissues. Since xenon is devoid of toxicity and relevant side effects, it could be beneficial at least in a subset of patients at high risk, and xenon therefore may become a reasonable alternative in this patient population.

摘要

惰性气体氙,除了具有麻醉和镇痛特性外,还展现出理想麻醉剂的诸多特征。然而,由于生产成本高昂,其在日常临床实践中的应用受到限制。近期研究表明,氙不仅具有出色的血流动力学稳定性和快速苏醒特性,还具备介导对各器官和组织缺血性损伤的保护能力。鉴于氙无毒且无相关副作用,至少对一部分高危患者可能有益,因此氙在这类患者群体中可能成为一种合理的替代选择。

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1
[Xenon--the ideal anaesthetic agent?].[氙气——理想的麻醉剂?]
Anasthesiol Intensivmed Notfallmed Schmerzther. 2007 Nov;42(11):784-91. doi: 10.1055/s-2007-1003591.
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[Xenon anaesthesia--clinical characteristics, benefits and disadvantages and fields of application].[氙气麻醉——临床特征、优缺点及应用领域]
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A practical rule for optimal flows for xenon anaesthesia in a semi-closed anaesthesia circuit.半紧闭麻醉回路中氙气麻醉的最佳流量实用规则。
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[Xenon--a new anesthetic].[氙气——一种新型麻醉剂]
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[Xenon - noble gas with organprotective properties].[氙气——具有器官保护特性的惰性气体]
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The haemodynamic and catecholamine response to xenon/remifentanil anaesthesia in Beagle dogs.比格犬对氙气/瑞芬太尼麻醉的血流动力学和儿茶酚胺反应。
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Xenon, a modern anaesthesia gas.氙气,一种现代麻醉气体。
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Xenon elimination kinetics following brief exposure.短暂暴露后的氙消除动力学。
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Inhalation anaesthesia: from diethyl ether to xenon.吸入麻醉:从乙醚到氙气。
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Xenon: recent developments and future perspectives.氙气:最新进展与未来展望
Minerva Anestesiol. 2009 Jan-Feb;75(1-2):37-45. Epub 2008 May 15.

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The Anaesthetics Isoflurane and Xenon Reverse the Synaptotoxic Effects of Aβ on Megf10-Dependent Astrocytic Synapse Elimination and Spine Density in Ex Vivo Hippocampal Brain Slices.麻醉剂异氟烷和氙气逆转了 Aβ 对 Megf10 依赖性星形胶质细胞突触消除和脑片中海马突触棘密度的突触毒性作用。
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The Role of Heme Oxygenase-1 in Remote Ischemic and Anesthetic Organ Conditioning.血红素加氧酶-1在远程缺血与麻醉器官预处理中的作用
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Anesthetic gases and global warming: Potentials, prevention and future of anesthesia.
麻醉气体与全球变暖:麻醉的潜在影响、预防措施及未来发展
Anesth Essays Res. 2011 Jan-Jun;5(1):5-10. doi: 10.4103/0259-1162.84171.
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The breast feeding mother and xenon anaesthesia: four case reports. Breast feeding and xenon anaesthesia.母乳喂养母亲与氙气麻醉:四例报告。母乳喂养与氙气麻醉。
BMC Anesthesiol. 2010 Feb 19;10:1. doi: 10.1186/1471-2253-10-1.