Rafecas I, Esteve M, Remesar X, Alemany M
Departament de Bioquímica i Fisiologia, Universitat de Barcelona, Spain.
Biochem Int. 1991 Dec;25(5):797-806.
Plasma amino acids of Zucker obese (fa/fa) and lean (Fa/?) rats fed either a reference nonpurified pellet or a cafeteria diet have been studied from 30 to 60 days after birth. Obese rats showed higher plasma branched chain amino acid levels but similar total amino acids, urea and glucose concentrations. The ingestion of a cafeteria diet induced higher levels in many amino acids, as well as in the composite figure in lean rats, but failed to alter total 2-amino nitrogen concentrations in obese rats, despite high levels in several non-essential amino acids and lower values in essential amino acids; urea levels were much lower in rats fed the cafeteria diet. The results are consistent with an impairment of amino acid nitrogen elimination via urea cycle in cafeteria diet-fed rats. This is independent of the hyperinsulinemia-driven plasma accumulation of several essential amino acids induced by genetic obesity. The effects were, then additive.
对出生后30至60天喂食标准非纯化颗粒饲料或自选饮食的 Zucker 肥胖（fa/fa）大鼠和瘦（Fa/?）大鼠的血浆氨基酸进行了研究。肥胖大鼠的血浆支链氨基酸水平较高，但总氨基酸、尿素和葡萄糖浓度相似。自选饮食的摄入使瘦大鼠的许多氨基酸以及综合指标水平升高，但尽管几种非必需氨基酸水平较高而必需氨基酸水平较低，却未能改变肥胖大鼠的总2-氨基氮浓度；喂食自选饮食的大鼠尿素水平要低得多。结果表明，喂食自选饮食的大鼠通过尿素循环消除氨基酸氮的功能受损。这与遗传肥胖引起的高胰岛素血症驱动的几种必需氨基酸的血浆蓄积无关。这些影响是相加的。
