Segués T, Salvadó J, Arola L, Alemany M
Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Tarragona, Spain.
Biochem Mol Biol Int. 1994 May;33(2):321-8.
The long-term effects of cafeteria diet feeding were studied by comparing the circulating levels of glucose, lactate, glycerol, 3-hydroxybutyrate and urea, and liver glycogen in female Wistar rats offered the diet from birth (CB) or from 30 days (C30) after birth, compared with controls fed on a standard reference diet. Body weight was maximal for CB, distinctly higher than that of C30, which in turn were heavier than controls. Growth rates, however, were similar for most of the period studied. Plasma glucose homeostasis was maintained fully in all three groups, with a remarkable lack of changes in liver glycogen concentration. The patterns of lactate and glycerol concentration changed with age. Different initial settings converged to adult values in all groups. The higher ability of cafeteria rats to use lipids as energy fuel is in agreement with their higher circulating levels of 3-hydroxybutyrate, a factor that may be essential in the shift to increased fat deposition that characterizes prolonged cafeteria feeding. Urea levels were highest in controls, and lowest in cafeteria rats fed from day 30, a consequence of the different setting of nitrogen sparing induced by the timing of initiation of cafeteria feeding. From the results presented it can be postulated that the type of diet onto which the rats are weaned may significantly affect their weight and metabolic correlations much later in life.
通过比较从出生起（CB）或出生后30天（C30）开始食用该饮食的雌性Wistar大鼠与喂食标准参考饮食的对照组大鼠的血糖、乳酸、甘油、3-羟基丁酸和尿素的循环水平以及肝糖原，研究了自助餐式饮食喂养的长期影响。CB组的体重最大，明显高于C30组，而C30组又比对照组重。然而，在研究的大部分时间里，生长速率相似。所有三组的血浆葡萄糖稳态均得到充分维持，肝糖原浓度明显没有变化。乳酸和甘油浓度的模式随年龄而变化。所有组中不同的初始状态都趋向于成年值。自助餐式饮食喂养的大鼠利用脂质作为能量燃料的能力较高，这与其循环中较高水平的3-羟基丁酸一致，这一因素可能对向以长期自助餐式饮食喂养为特征的脂肪沉积增加的转变至关重要。对照组的尿素水平最高，从第30天开始喂食的自助餐式饮食喂养的大鼠尿素水平最低，这是由于自助餐式饮食喂养开始时间不同导致的氮节约设置不同的结果。从所呈现的结果可以推测，大鼠断奶时的饮食类型可能会在其生命后期显著影响其体重和代谢相关性。
