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泰国患者肝细胞癌和胆管癌标本中幽门螺杆菌VacA基因特异性检测

Detection of VacA gene specific for Helicobactor pylori in hepatocellular carcinoma and cholangiocarcinoma specimens of Thai patients.

作者信息

Leelawat Kawin, Suksumek Nithikoon, Leelawat Surang, Lek-Uthai Usa

机构信息

Division of Surgery, Rajavithi Hospital, Bangkok, Thailand.

出版信息

Southeast Asian J Trop Med Public Health. 2007 Sep;38(5):881-5.

PMID:18041306
Abstract

In order to investigate and compare the presence of Helicobacter pylori VacA in primary liver cancer specimens (12 hepatocellular carcinoma and 6 cholangiocarcinoma) and control liver specimens (7 non-primary liver cancer) from Thai patients who underwent liver resection, H. pylori VacA gene was assayed in extracted DNA by real-time polymerase chain reaction. The selected amplicons revealed high homology compared with H. pylori VacA sequence. H. pylori VacA gene was detected in all primary liver cancer specimens and in 71% (5/7) of control liver specimens.

摘要

为了调查和比较原发性肝癌标本（12例肝细胞癌和6例胆管癌）与来自接受肝切除的泰国患者的对照肝脏标本（7例非原发性肝癌）中幽门螺杆菌空泡毒素A（VacA）的存在情况，通过实时聚合酶链反应在提取的DNA中检测幽门螺杆菌VacA基因。所选扩增子与幽门螺杆菌VacA序列相比显示出高度同源性。在所有原发性肝癌标本以及71%（5/7）的对照肝脏标本中检测到幽门螺杆菌VacA基因。

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