泰国北部胃病患者的幽门螺杆菌cagA、vacA和iceA基因型
Helicobacter pylori cagA, vacA and iceA genotypes in northern Thai patients with gastric disease.
作者信息
Linpisarn Sukanya, Suwan Warissara, Lertprasertsuk Nirush, Koosirirat Chuchart, Steger Heinrich F, Prommuangyong Kunrunya, Phornphutkul Kannikar
机构信息
Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50202, Thailand.
出版信息
Southeast Asian J Trop Med Public Health. 2007 Mar;38(2):356-62.
Helicobacterpylori, a common infectious bacterium, has been linked to chronic gastritis, peptic ulcer and gastric cancer. Gastric biopsy specimens were obtained from 58 northern Thai patients with gastritis, 28 with gastric ulcer, 45 with duodenal ulcer and 4 with gastric cancer. cagA, vacA s1 and iceA gene was found in 88, 98, and 89% of the specimens, respectively. For vacA, the frequency of subtype s1a, s1c and combined sla and s1c was 40, 16, and 41%, respectively. The frequency of subtype s1a/m1 and s1a/s1c/m1 was 27 and 20%, respectively. Fifty-three patients (39%) were infected with multiple vacA genotypes but there was no association with clinical outcome. cagA positive and mixed vacA s1a and s1c strains were found in significantly more cases of duodenal ulcer than gastritis (p < 0.05). For iceA, subtype iceA1 reached a frequency of 60%, whereas subtype iceA2 was only 24%.
幽门螺杆菌是一种常见的传染性细菌，与慢性胃炎、消化性溃疡和胃癌有关。从58名泰国北部胃炎患者、28名胃溃疡患者、45名十二指肠溃疡患者和4名胃癌患者中获取胃活检标本。分别在88%、98%和89%的标本中发现了cagA、vacA s1和iceA基因。对于vacA，亚型s1a、s1c以及s1a和s1c组合的频率分别为40%、16%和41%。亚型s1a/m1和s1a/s1c/m1的频率分别为27%和20%。53名患者（39%）感染了多种vacA基因型，但这与临床结果无关。十二指肠溃疡患者中cagA阳性以及vacA s1a和s1c混合菌株的病例明显多于胃炎患者（p<0.05）。对于iceA，亚型iceA1的频率达到60%，而亚型iceA2仅为24%。
Zotero 插件