Anokhina I P, Gorkin V Z, Medvedev A E, Ovchinnikova L N, Khristolyubova N A
All-Union Research Centre for Medico-Biological Problems of Narcology, Ministry of Public Health, Moscow, U.S.S.R.
Alcohol Alcohol. 1991;26(5-6):559-65. doi: 10.1093/oxfordjournals.alcalc.a045159.
In the liver mitochondrial fraction of the first generation offspring of alcoholized male rats, decreased activities of monoamine oxidase (MAO) types A and B, rotenone-insensitive NADH-cytochrome c-reductase and succinate dehydrogenase were observed. The MAO-dependent inhibition of rotenone-insensitive NADH-cytochrome c-reductase and succinate dehydrogenase by biogenic amines, incubated with the mitochondrial fraction, was altered in the offspring of alcoholized animals as compared with control rats. The sensitivity of these enzymatic activities towards the inhibitory effect of 5-methoxyindol-3-ylacetaldehyde was markedly increased in the offspring of alcoholized male rats. The data obtained suggest the existence of a genetically determined predisposition of the mitochondrial metabolic processes in the offspring of the alcoholized rats to the effects of ethanol and to the toxic effects of acetaldehyde, formed during ethanol metabolism.
在酒精处理的雄性大鼠第一代子代的肝脏线粒体组分中，观察到A和B型单胺氧化酶（MAO）、鱼藤酮不敏感的NADH - 细胞色素c还原酶以及琥珀酸脱氢酶的活性降低。与对照大鼠相比，与线粒体组分一起孵育的生物胺对鱼藤酮不敏感的NADH - 细胞色素c还原酶和琥珀酸脱氢酶的MAO依赖性抑制作用在酒精处理动物的子代中发生了改变。在酒精处理的雄性大鼠子代中，这些酶活性对5 - 甲氧基吲哚 - 3 - 基乙醛抑制作用的敏感性显著增加。所获得的数据表明，酒精处理大鼠子代的线粒体代谢过程存在遗传决定的易感性，易受乙醇及其在乙醇代谢过程中形成的乙醛的毒性作用影响。
