爱泼斯坦-巴尔病毒对霍奇金淋巴瘤分子发病机制的作用。
Contribution of the Epstein Barr virus to the molecular pathogenesis of Hodgkin lymphoma.
作者信息
Kapatai G, Murray P
机构信息
The Cancer Research UK Institute for Cancer Studies, Medical School, University of Birmingham, Birmingham, UK.
出版信息
J Clin Pathol. 2007 Dec;60(12):1342-9. doi: 10.1136/jcp.2007.050146.
Abstract
Although the morphology of the pathognomonic Reed-Sternberg cells of Hodgkin lymphoma (HL) was described over a century ago, it was not until recently that their origin from B lymphocytes was recognised. The demonstration that a proportion of cases of HL harbour the Epstein-Barr virus (EBV) and that its genome is monoclonal in these tumours suggests that the virus contributes to the development of HL in some cases. This review summarises current knowledge of the pathogenesis of HL with particular emphasis on the association with EBV.
摘要
尽管霍奇金淋巴瘤（HL）中具有诊断意义的里德-斯腾伯格细胞的形态在一个多世纪前就已被描述，但直到最近才认识到它们起源于B淋巴细胞。有证据表明，一部分HL病例携带爱泼斯坦-巴尔病毒（EBV），并且在这些肿瘤中其基因组是单克隆的，这表明该病毒在某些情况下促成了HL的发生。这篇综述总结了HL发病机制的当前知识，特别强调了与EBV的关联。
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