人类嗜T淋巴细胞病毒I型感染与成人T细胞白血病/淋巴瘤的分子学方面
Molecular aspects of HTLV-I infection and adult T-cell leukaemia/lymphoma.
作者信息
Taylor G
机构信息
Infectious Diseases Section, Division of Medicine Faculty, St Mary's Campus, Imperial College London, London, UK.
出版信息
J Clin Pathol. 2007 Dec;60(12):1392-6. doi: 10.1136/jcp.2007.052662.
Abstract
Human T-cell lymphotropic virus-I (HTLV-I) is the cause of adult T-cell leukaemia/lymphoma. Various viral proteins, especially, but not exclusively, Tax have been implicated in oncogenesis, mostly through in vitro studies. Tax transactivates a large and apparently ever expanding list of human genes through transcriptional factors. Elucidating not only the pathways but also the timing of action of HTLV proteins is important for understanding the pathogenesis and development of new treatments.
摘要
人类嗜T细胞病毒I型（HTLV-I）是成人T细胞白血病/淋巴瘤的病因。多种病毒蛋白，特别是但不限于Tax蛋白，已被认为与肿瘤发生有关，这主要是通过体外研究得出的结论。Tax蛋白通过转录因子反式激活大量且明显不断增加的人类基因。不仅阐明HTLV蛋白的作用途径，而且明确其作用时机，对于理解发病机制和开发新的治疗方法都很重要。
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