Sundquist Jan, Li Xinjun, Sundquist Kristina, Hemminki Kari
Center for Family and Community Medicine, Karolinska Institutet, Huddinge, Sweden.
Neuroepidemiology. 2007;29(3-4):178-84. doi: 10.1159/000111580. Epub 2007 Nov 27.
This nationwide study aimed to enhance available data by determining sibling risks of subarachnoid hemorrhage in a total population. The MigMed database at the Karolinska Institute, Stockholm, was used to identify all cases of subarachnoid hemorrhage diagnosed in Sweden between 1987 and 2001. Incidence ratios standardized for age, region, and socioeconomic status (SIRs) were calculated for persons with at least 1 sibling with subarachnoid hemorrhage. The reference group consisted of persons whose siblings had no subarachnoid hemorrhage. A total of 90 affected siblings were identified; their SIR of subarachnoid hemorrhage was 2.75. The risk decreased with increasing age in both men and women. Within the limits of the sample size, no sex differences could be observed. The relatively high sibling risks are likely to be due to heritable causes and shared environmental factors. Genetic causes possibly weigh more in early- than late-onset cases. This study shows the feasibility of carrying out nationwide family studies on subarachnoid hemorrhage.
这项全国性研究旨在通过确定总人口中蛛网膜下腔出血的同胞风险来增加现有数据。利用斯德哥尔摩卡罗林斯卡学院的MigMed数据库，识别出1987年至2001年期间在瑞典诊断出的所有蛛网膜下腔出血病例。对至少有1名患蛛网膜下腔出血同胞的人计算年龄、地区和社会经济地位标准化发病率（SIRs）。参照组由其同胞未患蛛网膜下腔出血的人组成。共识别出90名受影响的同胞；他们蛛网膜下腔出血的SIR为2.75。男性和女性的风险均随年龄增长而降低。在样本量的限制范围内，未观察到性别差异。相对较高的同胞风险可能归因于遗传因素和共同的环境因素。遗传因素在早发病例中可能比晚发病例中所占比重更大。这项研究表明了开展全国性蛛网膜下腔出血家族研究的可行性。
