Sundquist Jan, Li Xinjun, Friberg Danielle, Hemminki Kari, Sundquist Kristina
Karolinska Institute, Center for Family and Community Medicine, Huddinge, Sweden.
Sleep. 2008 Jun;31(6):817-23. doi: 10.1093/sleep/31.6.817.
Understanding the genetic transmission of obstructive sleep apnea syndrome (OSAS) will help clinicians identify patients at risk and offer opportunities for intervention and treatment at specialist clinics.
To estimate familial risk of hospitalization for OSAS in the adult population of Sweden, and to determine if there are any differences by age and sex.
DESIGN, SETTING, AND PARTICIPANTS: Using the MigMed database at the Karolinska Institute, we divided the population of Sweden into sibling groups based on a shared mother and father and ascertained the presence or absence of a primary hospital diagnosis of OSAS in each individual during the follow-up period, 1997 to 2004. Individuals were categorized as having or not having a sibling with OSAS, based on the presence or absence of the disorder in at least 1 of their siblings. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were estimated for men and women with a sibling with OSAS, compared with men and women in the reference group (SIR = 1).
After accounting for socioeconomic status, age, geographic region, and period of diagnosis, men with at least 1 sibling who had OSAS had a SIR of 3.42 (95% CI, 2.18-5.36); the corresponding SIR in women was 3.25 (95% CI, 1.84-5.65).
Our results indicate that physicians should consider family history of OSAS when deciding whether to refer a patient for further sleep examinations.
了解阻塞性睡眠呼吸暂停综合征（OSAS）的遗传传递情况将有助于临床医生识别有风险的患者，并为专科诊所提供干预和治疗的机会。
估计瑞典成年人群中因OSAS住院的家族风险，并确定年龄和性别是否存在差异。
设计、设置和参与者：利用卡罗林斯卡学院的MigMed数据库，我们根据共同的父母将瑞典人口划分为兄弟姐妹组，并确定了1997年至2004年随访期间每个人是否有OSAS的主要医院诊断。根据至少一个兄弟姐妹是否患有该疾病，将个体分类为有或没有患有OSAS的兄弟姐妹。与参考组（SIR = 1）中的男性和女性相比，估计有患有OSAS的兄弟姐妹的男性和女性的标准化发病率（SIR）及其95%置信区间（CI）。
在考虑社会经济地位、年龄、地理区域和诊断时间后，至少有一个患有OSAS的兄弟姐妹的男性的SIR为3.42（95% CI，2.18 - 5.36）；女性相应的SIR为3.25（95% CI，1.84 - 5.65）。
我们的结果表明，医生在决定是否将患者转诊进行进一步的睡眠检查时应考虑OSAS的家族史。
