Jacobs Deborah S, Rosenthal Perry
Boston Foundation for Sight, Needham, MA 02494, USA.
Cornea. 2007 Dec;26(10):1195-9. doi: 10.1097/ICO.0b013e318155743d.
To determine if the Boston Scleral Lens Prosthetic Device (BSLPD) reduces symptoms and improves quality of life in patients with severe dry eye from chronic graft-versus-host disease (cGvHD).
This is a noncomparative interventional case series reporting 33 consecutive patients with severe dry eye from cGvHD, unresponsive to conventional therapy, who were fitted with the BSLPD. A patient survey was undertaken after lenses were dispensed and worn regarding the effect of scleral lens wear on their symptoms, quality of life, and activities of daily living. The patient population was characterized from a retrospective chart review. Survey data were tabulated.
BSLPD wear resulted in improvement in pain, photophobia, and general quality of life in nearly all patients, with more than half reporting the highest improvement level for pain (52%) and photophobia (63%), and more than two thirds (73%) reporting the highest improvement level for quality of life. There was improvement in reading and driving in >90% of those who reported previous compromise, with >60% reporting the highest improvement level for each of these activities.
The BSLPD mitigates symptoms and improves quality of life in patients with severe dry eye from cGHvD.
确定波士顿巩膜镜片假体装置（BSLPD）是否能减轻慢性移植物抗宿主病（cGvHD）所致严重干眼症患者的症状并改善其生活质量。
这是一个非对照性干预病例系列，报告了33例连续的cGvHD所致严重干眼症患者，他们对传统治疗无反应，均佩戴了BSLPD。在镜片分发并佩戴后，对患者进行了一项关于巩膜镜片佩戴对其症状、生活质量和日常生活活动影响的调查。通过回顾性病历审查对患者群体进行了特征描述。对调查数据进行了制表。
几乎所有患者佩戴BSLPD后疼痛、畏光和总体生活质量均有改善，超过一半的患者报告疼痛（52%）和畏光（63%）改善程度最高，超过三分之二（73%）的患者报告生活质量改善程度最高。在报告之前存在阅读和驾驶障碍的患者中，超过90%的人在这两项活动中有改善，超过60%的人报告这两项活动的改善程度最高。
BSLPD可减轻cGHvD所致严重干眼症患者的症状并改善其生活质量。
