Rodgers Steven E, Lew John I, Solórzano Carmen C
Division of Endocrine Surgery, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
Curr Opin Oncol. 2008 Jan;20(1):52-8. doi: 10.1097/CCO.0b013e3282f2838f.
This article reviews the diagnosis and treatment of primary hyperparathyroidism, including recent literature on the subject.
Important recent advancements in the field of parathyroid disease include improvements in preoperative localization, the use of intraoperative parathyroid hormone monitoring, and the development of minimally invasive and videoscopic surgical techniques. Additionally, there has been significant interest in better understanding the clinical changes and presentation of sporadic primary hyperparathyroidism, including the assessment of neurocognitive symptoms before and after surgery. This has led to a change in the definition of the 'asymptomatic patient' and altered the criteria used to trigger surgical intervention.
Although the cause of primary hyperparathyroidism is still poorly understood, surgical parathyroidectomy results in long-term cure in greater than 95% of cases. Improvements in our understanding of this disease continue to make diagnosis and treatment safer and more effective.
本文综述原发性甲状旁腺功能亢进症的诊断与治疗，包括该主题的近期文献。
甲状旁腺疾病领域近期的重要进展包括术前定位的改善、术中甲状旁腺激素监测的应用以及微创和视频辅助手术技术的发展。此外，人们对更好地理解散发性原发性甲状旁腺功能亢进症的临床变化和表现有了浓厚兴趣，包括手术前后神经认知症状的评估。这导致了“无症状患者”定义的改变，并改变了触发手术干预的标准。
尽管原发性甲状旁腺功能亢进症的病因仍了解不足，但手术切除甲状旁腺在超过95%的病例中可实现长期治愈。我们对该疾病认识的提高继续使诊断和治疗更安全、更有效。
