Akçay Müfide Nuran, Akçay Güngör
Atatürk University, Faculty of Medicine, Department of General Surgery, Erzurum, Turkey.
Atatürk University, Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology, Erzurum, Turkey.
Eurasian J Med. 2009 Aug;41(2):108-9.
Primary hyperparathyroidism (pHPT) is a disease in which the diagnosis depends increasingly on laboratory tests since the majority of patients are elderly people without typical symptoms. The aim of this study was to calculate the specificity and sensitivity rates, and positive predictive value of blood Ca, P, ALP, and iPTH levels in patients with PA.
We calculated the specificity and sensitivity rates, and positive predictive value of blood calcium (Ca), phosphorous (P), alkaline phosphatase (ALP), and intact parathormone (iPTH) levels in patients with sporadic and solitary parathyroid adenoma (PA).
Twenty six patients with PA were included in the study. The mean age was 44.5±14.9 (18-70) years. Blood levels of Ca, P, ALP, and iPTH were 2.5±0.3 mmol/L, 0.8±0.3 mmol/L, 21.4±31.5 μkat/L, and 518.0±633.4 ng/L, respectively. With respect to the diagnosis of pHPT, the sensitivity of blood levels of iPTH, P, Ca, and ALP were 96%, 94%, 81%, and 73%, respectively. The specificity and positive predictive value of all parameters were 100% for the diagnosis of PA.
Routine laboratory parameters are specific and predictive for pHPT. However, the sensitivities of P and iPTH are higher than those other parameters.
原发性甲状旁腺功能亢进症（pHPT）是一种多数患者为无典型症状的老年人，其诊断越来越依赖实验室检查的疾病。本研究的目的是计算甲状旁腺腺瘤（PA）患者血钙、血磷、碱性磷酸酶（ALP）和全段甲状旁腺激素（iPTH）水平的特异性、敏感性及阳性预测值。
我们计算了散发性孤立性甲状旁腺腺瘤（PA）患者血钙（Ca）、血磷（P）、碱性磷酸酶（ALP）和全段甲状旁腺激素（iPTH）水平的特异性、敏感性及阳性预测值。
本研究纳入了26例PA患者。平均年龄为44.5±14.9（18 - 70）岁。血钙、血磷、ALP和iPTH水平分别为2.5±0.3 mmol/L、0.8±0.3 mmol/L、21.4±31.5 μkat/L和518.0±633.4 ng/L。对于pHPT的诊断，iPTH、血磷、血钙和ALP水平的敏感性分别为96%、94%、81%和73%。所有参数对PA诊断的特异性和阳性预测值均为100%。
常规实验室参数对pHPT具有特异性和预测性。然而，血磷和iPTH的敏感性高于其他参数。
