人类白血病组织DNA中狒狒内源性C型RNA病毒的前病毒序列。
Proviral sequences of baboon endogenous type C RNA virus in DNA of human leukaemic tissues.
作者信息
Wong-Staal F, Gillespie D, Gallo R C
出版信息
Nature. 1976 Jul 15;262(5565):190-5. doi: 10.1038/262190a0.
DOI:10.1038/262190a0
PMID:180434
Abstract
Hybridisation of RNA from a baboon endogenous type C RNA virus to DNA from tissues of leukaemic patients indicates that a virus of this type is horizontally transmitted among humans. DNA from several patients with leukaemia hybridised 70% of the hybridisable RNA from baboon endogenous type C RNA virus (BaEV) and yielded hybrids of high tm, whereas DNA from normal human tissues hybridised only 23% of the BaEV RNA, and the tm of these hybrids was lower.
摘要
来自狒狒内源性C型RNA病毒的RNA与白血病患者组织的DNA杂交表明，这种类型的病毒在人类之间存在水平传播。几位白血病患者的DNA与狒狒内源性C型RNA病毒（BaEV）70%的可杂交RNA杂交，并产生了高熔解温度（tm）的杂交体，而来自正常人体组织的DNA仅与23%的BaEV RNA杂交，且这些杂交体的tm较低。
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